{"id":"W4225693177","doi":"10.1208/s12249-022-02258-0","title":"In Vitro Evaluation of a Foamable Microemulsion Towards an Improved Topical Delivery of Diclofenac Sodium","year":2022,"lang":"en","type":"article","venue":"AAPS PharmSciTech","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Transdermal; Zeta potential; Microemulsion; Diclofenac Sodium; Stratum corneum; Particle size; Chromatography; Solubility; Chemistry; Active ingredient; Materials science; Chemical engineering; Biomedical engineering; Nanotechnology; Pharmacology; Pulmonary surfactant; Organic chemistry; Nanoparticle; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002133945,0.0002069493,0.0003709598,0.0002810784,0.000161484,0.000004667635,0.0004952737,0.0001534534,0.002879639],"category_scores_gemma":[0.00005047271,0.0002282591,0.0001146838,0.000470658,0.0001747271,0.0003126181,0.0002645925,0.0008084556,0.00000578242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00028291,"about_ca_system_score_gemma":0.000232161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001995051,"about_ca_topic_score_gemma":0.00001364327,"domain_scores_codex":[0.9968433,0.001054339,0.0006694409,0.0004159833,0.0005990437,0.0004178295],"domain_scores_gemma":[0.9989483,0.0001397611,0.0002547699,0.0003043069,0.0002413378,0.000111545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001958756,0.001199606,0.0007803046,0.00007033995,0.00007202836,0.00001442592,0.0009054726,0.003162631,0.9247019,0.00005047208,0.0002538694,0.06683021],"study_design_scores_gemma":[0.005517922,0.0003102174,0.0004764128,0.000007810245,0.0002089987,0.00001318518,0.0003528432,0.0670253,0.9154506,0.0009233135,0.009486372,0.0002270411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955374,0.0009124684,0.0002794664,0.0003360821,0.001087549,0.0008687355,0.0002417145,0.00003355014,0.0007030264],"genre_scores_gemma":[0.997579,0.0001261931,0.0007799444,0.0009061972,0.00007967289,0.0002189526,0.0000936915,0.00002579803,0.0001905834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06660317,"threshold_uncertainty_score":0.9980319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1040632540785273,"score_gpt":0.4401850833731365,"score_spread":0.3361218292946092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}