{"id":"W4225699254","doi":"10.1186/s13578-021-00723-0","title":"Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2","year":2021,"lang":"en","type":"article","venue":"Cell & Bioscience","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; McMaster University; Sunnybrook Health Science Centre; University of Waterloo; SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Nasal administration; Medicine; Immunization; Virology; Immunology; Immunity; Coronavirus disease 2019 (COVID-19); Respiratory system; Regimen; Transmission (telecommunications); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Respiratory tract; Pandemic; Antibody; Immune system; Disease; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856492,0.0005003876,0.0002218132,0.0002727775,0.000140241,0.0001777238,0.000200298,0.0003800046,0.001913442],"category_scores_gemma":[0.00006504008,0.0001392401,0.0002242814,0.00007374393,0.0002464381,0.0002797481,0.0001092011,0.001100985,0.0005514323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002337071,"about_ca_system_score_gemma":0.0002272673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002870773,"about_ca_topic_score_gemma":0.0003869342,"domain_scores_codex":[0.9998777,0.00001285039,0.00001349043,0.00003144646,0.00002687805,0.0000376725],"domain_scores_gemma":[0.9999225,0.000009062395,0.00002092109,0.00001163493,0.00000952353,0.00002631585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002051283,0.0002269659,0.0001744851,0.0000266755,0.000003353289,0.00002594073,0.00001317689,0.00004937835,0.9980336,0.00007832758,0.0000685242,0.001094527],"study_design_scores_gemma":[0.00009633213,0.002314853,0.002929047,0.000009345877,0.00001571238,0.0002575091,0.00002850833,0.0009374098,0.9908059,0.00005916704,0.002542214,0.000003851874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929013,0.0006498803,0.003577258,0.0002306825,0.00007381457,0.00008440154,0.0006853023,0.0001458937,0.001651453],"genre_scores_gemma":[0.9830533,0.0007125424,0.006402082,0.0002147019,0.00003745666,0.0001418492,0.001589465,0.00004055558,0.007807921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001913442,"threshold_uncertainty_score":0.006401062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03811976955228367,"score_gpt":0.3213387022395335,"score_spread":0.2832189326872498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}