{"id":"W4225702197","doi":"10.1101/2021.11.01.466743","title":"Platelet generation from circulating megakaryocytes is triggered in the lung vasculature","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"University of Bristol; British Heart Foundation; Wellcome Trust","keywords":"Platelet; Megakaryocyte; Lung; Ex vivo; Bone marrow; Cell biology; Biology; Pathology; In vivo; Immunology; Medicine; Internal medicine; Progenitor cell; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213963,0.0001377387,0.0001898613,0.0001307698,0.0001594229,0.0003969455,0.0001354696,0.0003170064,0.001950401],"category_scores_gemma":[0.0001741603,0.000124768,0.0001324794,0.00008556963,0.0001790964,0.000173141,0.0002433945,0.0004660857,0.0005167432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002179245,"about_ca_system_score_gemma":0.0001248913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001385274,"about_ca_topic_score_gemma":0.0001505822,"domain_scores_codex":[0.9998976,0.00001691795,0.000005331369,0.00002462944,0.00003652845,0.00001901326],"domain_scores_gemma":[0.9999117,0.00002885391,0.00002315719,0.000008348913,0.00001051197,0.00001752129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008049312,0.000006100095,0.0002740405,0.000030608,0.000002409122,0.00008004873,0.00001629216,0.00003982339,0.9977793,0.0002399112,0.0001650865,0.001285856],"study_design_scores_gemma":[0.0000291233,0.0001484812,0.01131374,0.00001404283,0.0000112643,0.000363108,0.00003396634,0.001724472,0.9807646,0.0002930944,0.005297734,0.000006441005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780781,0.004167014,0.01121921,0.0006150555,0.0001533087,0.00003438842,0.0006458159,0.000238257,0.004848891],"genre_scores_gemma":[0.992147,0.0009215989,0.002848389,0.0001323584,0.00005567573,0.00003489119,0.0003184218,0.00003782898,0.003503841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001950401,"threshold_uncertainty_score":0.006524801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894105128940569,"score_gpt":0.2378614425960826,"score_spread":0.2189203913066769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}