{"id":"W4225727164","doi":"10.1002/trc2.12289","title":"Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care; Kingston Health Sciences Centre; Queen's University","funders":"Fondation Brain Canada","keywords":"Cerebrospinal fluid; Rhesus macaque; Cisterna magna; Macaque; Lumbar puncture; Biomarker; Medicine; Pathology; Lumbar; Physiology; Biology; Neuroscience; Immunology; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001037356,0.0002029938,0.0004515518,0.0005376865,0.0004620539,0.00003880755,0.0001757667,0.00007294792,0.001013643],"category_scores_gemma":[0.0002485444,0.000188291,0.0003522132,0.0009371476,0.0005774416,0.0002282177,0.0001419804,0.0006553988,0.000007304901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005719259,"about_ca_system_score_gemma":0.0006988621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001828174,"about_ca_topic_score_gemma":0.0002226947,"domain_scores_codex":[0.9948301,0.001582878,0.001063494,0.0006180914,0.001374165,0.0005313238],"domain_scores_gemma":[0.9978139,0.0007248101,0.0002036811,0.0002761841,0.0004864672,0.0004949432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009508778,0.01059287,0.9191031,0.0001076547,0.04881817,0.0002110798,0.0001314957,0.00003566662,0.0006935318,0.001383069,0.0002111291,0.009203398],"study_design_scores_gemma":[0.00605661,0.005483878,0.9825527,0.0002412336,0.002798817,0.00001160666,0.0001052249,0.001741275,0.0002649557,0.0004687444,0.0001076101,0.0001673237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802935,0.0128351,0.0002439489,0.003329552,0.0000816333,0.001745207,0.00124384,0.00003163274,0.0001955752],"genre_scores_gemma":[0.9961021,0.0004281974,0.0002052207,0.00009423862,0.00003984684,0.0005379058,0.002542356,0.00003526024,0.00001489773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06344957,"threshold_uncertainty_score":0.9998996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1832098485349961,"score_gpt":0.4558293424188868,"score_spread":0.2726194938838906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}