{"id":"W4225727643","doi":"10.7554/elife.74335","title":"Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Children's Hospital of Eastern Ontario","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Mitochondrial DNA; Biology; Proteomics; Mitochondrion; Genetics; Cell biology; Computational biology; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001975236,0.0002688458,0.0002060895,0.0008559141,0.0003357753,0.0004852883,0.0001709249,0.0002935561,0.001777903],"category_scores_gemma":[0.0003146782,0.0001280676,0.0001531646,0.0004621946,0.0003027823,0.0002420751,0.0003144802,0.000136309,0.0002651992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846382,"about_ca_system_score_gemma":0.0001025294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002346552,"about_ca_topic_score_gemma":0.00367777,"domain_scores_codex":[0.999897,0.000009740677,0.00001044275,0.00004241993,0.00001370944,0.00002660013],"domain_scores_gemma":[0.9997707,0.00002887288,0.0001107699,0.00001845703,0.00003039732,0.00004089705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007922458,0.00007615556,0.8855602,0.00005449288,0.0001056387,0.0004592904,0.0003590683,0.00006556092,0.1072241,0.00005542612,0.0001006246,0.005147271],"study_design_scores_gemma":[0.000001931758,0.00006751849,0.9976306,0.00000277908,0.0000176685,0.0003083262,0.000164693,0.00005769796,0.001631629,0.00001284412,0.0001028244,0.00000148535],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995037,0.00009507515,0.0001254141,0.000006164857,0.000001068031,0.000002475105,0.0001062192,0.000002603295,0.0001572686],"genre_scores_gemma":[0.9990512,0.00006819703,0.0002102097,0.00002073544,0.000003191887,0.000005021112,0.0002014162,0.000003237928,0.0004368626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002346552,"threshold_uncertainty_score":0.005947709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020645094324541,"score_gpt":0.2416773499380554,"score_spread":0.23147089899481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}