{"id":"W4225823707","doi":"10.1002/trc2.12253","title":"Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"National Institute of Mental Health; National Institute on Aging; University of North Carolina at Chapel Hill; Wellcome Trust","keywords":"Microglia; MERTK; Cytotoxicity; Biology; Computational biology; Neuroscience; Receptor; Chemistry; Cell biology; Biochemistry; Immunology; In vitro; Receptor tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007745816,0.001173331,0.001038105,0.001635881,0.0005322105,0.0008573916,0.0004952002,0.0005887289,0.00597853],"category_scores_gemma":[0.0005035333,0.0003451087,0.0006755914,0.0007636957,0.0002833121,0.000389493,0.0004915937,0.0009150277,0.001254993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001338668,"about_ca_system_score_gemma":0.0008782073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00197537,"about_ca_topic_score_gemma":0.003841794,"domain_scores_codex":[0.9995653,0.00007825567,0.00003117623,0.00008891935,0.0001869413,0.00004937779],"domain_scores_gemma":[0.9996095,0.00008853565,0.00007916464,0.00005142771,0.0001242192,0.00004721937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002821342,0.001495294,0.004765818,0.0008885692,0.0002627054,0.0002861286,0.0001052454,0.005407396,0.9018459,0.0009206013,0.004538687,0.07666227],"study_design_scores_gemma":[0.0004756731,0.00813891,0.01004377,0.00008138723,0.0004031038,0.0008843651,0.00006471119,0.005314861,0.9477748,0.0004360358,0.02629524,0.00008703326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.923961,0.01126245,0.01153122,0.0008645405,0.0001603266,0.001468616,0.02257291,0.00165932,0.02651953],"genre_scores_gemma":[0.9217577,0.009203193,0.02862243,0.0009316926,0.00007863844,0.001589531,0.02171961,0.0002045994,0.01589256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00597853,"threshold_uncertainty_score":0.02000016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6058343969213321,"score_gpt":0.5327216841955329,"score_spread":0.07311271272579922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}