{"id":"W4225856923","doi":"10.1038/s41598-022-10317-6","title":"Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé","keywords":"Leishmania donovani; Biology; Transcriptome; Amastigote; Immune system; Gene expression profiling; Cell biology; Gene expression; Parasite hosting; Leishmania; Immunology; Gene; Visceral leishmaniasis; Leishmaniasis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939167,0.0001841925,0.0003532436,0.0004266257,0.0001788723,0.0003374929,0.0000790495,0.0001869666,0.0006645328],"category_scores_gemma":[0.0002101644,0.0001245783,0.0002563884,0.0003194359,0.0001640707,0.0001452617,0.0002929276,0.000297261,0.0002925274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001049285,"about_ca_system_score_gemma":0.0001332203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003978761,"about_ca_topic_score_gemma":0.0007123035,"domain_scores_codex":[0.9998259,0.00002247051,0.00001037059,0.00005279747,0.00002848989,0.00006002717],"domain_scores_gemma":[0.9999111,0.00002226428,0.0000231273,0.000005864373,0.00002085095,0.00001682272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006879706,0.00003685661,0.02238358,0.000219723,0.00003384295,0.000147433,0.0002029634,0.0001601226,0.9709889,0.00008066124,0.0001994225,0.004858473],"study_design_scores_gemma":[0.00004703772,0.001157571,0.7754242,0.00008777661,0.000183919,0.00106307,0.001262387,0.003029795,0.2090869,0.0004788586,0.008136499,0.0000419075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941409,0.00186266,0.0007942487,0.00006279925,0.00001306719,0.00001912732,0.002431702,0.00004018036,0.000635216],"genre_scores_gemma":[0.9905643,0.001235304,0.001554525,0.0001379292,0.0000193048,0.00007984389,0.0049049,0.00001924608,0.001484695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006645328,"threshold_uncertainty_score":0.002223074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882663305233852,"score_gpt":0.2891224743163416,"score_spread":0.2702958412640031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}