{"id":"W4225921000","doi":"10.1371/journal.pone.0261103","title":"Similarities between bacterial GAD and human GAD65: Implications in gut mediated autoimmune type 1 diabetes","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; National Science Foundation of Sri Lanka; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Simon Fraser University; National Science Foundation","keywords":"Glutamate decarboxylase; Biology; Immune system; Microbiome; Immunology; Human microbiome; Gut flora; Epitope; Dysbiosis; Autoantibody; Type 1 diabetes; Beta cell; Islet; Antigen; Genetics; Antibody; Diabetes mellitus; Enzyme; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762322,0.0002698965,0.0002260842,0.0003458628,0.0001355041,0.0003670987,0.0001268507,0.0002256994,0.0006799346],"category_scores_gemma":[0.0004264214,0.00009757471,0.0002722514,0.000371289,0.0002340637,0.0002140095,0.0002772723,0.0001844652,0.0001849483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694742,"about_ca_system_score_gemma":0.0001860101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000482357,"about_ca_topic_score_gemma":0.0006089018,"domain_scores_codex":[0.9998677,0.00003679555,0.000009476205,0.00003960196,0.00002003213,0.00002635143],"domain_scores_gemma":[0.9998186,0.00003413938,0.0000827955,0.00001574237,0.00001042253,0.00003831108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001943704,0.0001552327,0.1185447,0.001152517,0.0002124655,0.003149073,0.0004484368,0.003629224,0.8147272,0.004725135,0.00051451,0.05079776],"study_design_scores_gemma":[0.0001177117,0.003118702,0.6803485,0.0004662017,0.0006932839,0.02147476,0.001880627,0.01714011,0.2075751,0.0109064,0.05616736,0.0001112341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866447,0.007975048,0.003407269,0.0002080613,0.00003736254,0.00001015102,0.0002015682,0.0000369689,0.001478792],"genre_scores_gemma":[0.9955578,0.001586706,0.002326944,0.00007856845,0.00001313917,0.000003286348,0.0002063076,0.000005685127,0.0002215365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006799346,"threshold_uncertainty_score":0.002274632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126605819613121,"score_gpt":0.2265105529558978,"score_spread":0.2052444947597666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}