{"id":"W4225922136","doi":"10.3389/fphys.2022.876327","title":"Editorial: Regulatory Mechanisms of Ca2+ Activated Ion Channels and Their Impact on Physiological/Pathophysiological Function","year":2022,"lang":"en","type":"editorial","venue":"Frontiers in Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Ion channel; Function (biology); Pathophysiology; Neuroscience; Chemistry; Biology; Biophysics; Cell biology; Biochemistry; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003320775,0.003824613,0.002407336,0.002215559,0.002078793,0.003876556,0.002316603,0.008990314,0.01213597],"category_scores_gemma":[0.008553153,0.0007924251,0.001955441,0.0007995439,0.001640775,0.003259399,0.0010595,0.01252827,0.01088471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002111244,"about_ca_system_score_gemma":0.001567777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009365442,"about_ca_topic_score_gemma":0.002315779,"domain_scores_codex":[0.9981761,0.000296613,0.0002168439,0.0002846521,0.0008847031,0.0001411148],"domain_scores_gemma":[0.9939334,0.002000557,0.0004169845,0.0001307515,0.002357293,0.001161071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006836661,0.00001560073,0.00002128671,0.0001855387,0.00001130671,0.0001488143,0.000005884733,0.00002818297,0.0001325951,0.0001980402,0.9953482,0.003836274],"study_design_scores_gemma":[0.0001089507,0.00005499987,0.0004463427,0.0003269132,0.00005704233,0.0006966208,0.0000257209,0.0002470769,0.0002647482,0.001099601,0.996649,0.00002315876],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00006189207,0.005205799,0.0001189045,0.01974084,0.9728693,0.00002314165,0.00004984843,0.00004735167,0.001882986],"genre_scores_gemma":[0.0004896896,0.003381797,0.00009246756,0.0140211,0.9723178,0.00002085076,0.00003464611,0.00002451932,0.009617059],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01213597,"threshold_uncertainty_score":0.04059893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007513298502340362,"score_gpt":0.2314323655323202,"score_spread":0.2239190670299798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}