{"id":"W4225934572","doi":"10.1186/s12863-022-01044-y","title":"Predicted coronavirus Nsp5 protease cleavage sites in the human proteome","year":2022,"lang":"en","type":"article","venue":"BMC Genomic Data","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Concordia University","funders":"National Institute of Standards and Technology; Lundbeckfonden","keywords":"Cleavage (geology); Coronavirus; Proteome; Protease; Virology; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Biology; Computational biology; Chemistry; Medicine; Genetics; Biochemistry; Enzyme; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002504939,0.0004588145,0.000210305,0.0007423618,0.0001497968,0.0002464623,0.0001473909,0.0003211893,0.001305347],"category_scores_gemma":[0.0004905657,0.0001119473,0.0004284524,0.0006138401,0.00008549092,0.000190849,0.0001694633,0.0001672649,0.0006000149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503367,"about_ca_system_score_gemma":0.0003522115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363987,"about_ca_topic_score_gemma":0.001710463,"domain_scores_codex":[0.999876,0.00001853596,0.00001093752,0.0000472216,0.00003274003,0.00001447172],"domain_scores_gemma":[0.9998069,0.00006636841,0.0000474357,0.00001392782,0.00004842862,0.00001693556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004285012,0.0004272776,0.2585973,0.001676838,0.0004988695,0.004620504,0.0003725083,0.09514524,0.4567236,0.001545524,0.01272791,0.1633795],"study_design_scores_gemma":[0.0001393036,0.000823948,0.3165484,0.0001934917,0.0004085453,0.00722891,0.0002544429,0.4200002,0.2224861,0.003782184,0.02807991,0.00005465008],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597203,0.001726194,0.01910822,0.0001523085,0.00002721194,0.00008521766,0.01627256,0.0007212599,0.002186724],"genre_scores_gemma":[0.9219537,0.0008235059,0.04204841,0.00008385769,0.0000161864,0.00006383373,0.03401794,0.0000491973,0.000943445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001363987,"threshold_uncertainty_score":0.004366815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08060577922781918,"score_gpt":0.2904639652603926,"score_spread":0.2098581860325734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}