{"id":"W4225934572","doi":"10.1186/s12863-022-01044-y","title":"Predicted coronavirus Nsp5 protease cleavage sites in the human proteome","year":2022,"lang":"en","type":"article","venue":"BMC Genomic Data","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Concordia University","funders":"National Institute of Standards and Technology; Lundbeckfonden","keywords":"Cleavage (geology); Coronavirus; Proteome; Protease; Virology; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Biology; Computational biology; Chemistry; Medicine; Genetics; Biochemistry; Enzyme; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006561349,0.0001307661,0.0001087316,0.00003497414,0.0002485407,0.00005128231,0.001566614,0.00004088101,0.0000640577],"category_scores_gemma":[0.00004569229,0.000104711,0.00003574852,0.00009516833,0.00003097336,0.000009951411,0.001768827,0.0001765978,0.00001109276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000203057,"about_ca_system_score_gemma":0.00009186716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009515244,"about_ca_topic_score_gemma":0.00006643061,"domain_scores_codex":[0.9989298,0.0001265061,0.0002796592,0.0002988411,0.0001410781,0.0002241194],"domain_scores_gemma":[0.998358,0.000008064379,0.0001098623,0.001485783,0.000009987616,0.00002836918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004154691,0.0006896942,0.04194164,0.0001858177,0.0001005701,0.0000127719,0.001345551,0.0005054582,0.9080722,0.000290331,0.04449633,0.001944158],"study_design_scores_gemma":[0.006735612,0.002254643,0.2989931,0.00002581826,0.0001292697,0.0003062263,0.01011834,0.009592604,0.01804839,0.000469508,0.6518235,0.001503052],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962474,0.000420005,0.0001166694,0.00007274323,0.000040346,0.001116284,0.00108368,0.00001097042,0.0008919133],"genre_scores_gemma":[0.9882054,0.00001486781,0.0007733032,0.0002683239,0.0001054867,0.0003035068,0.009984346,0.00001990291,0.0003248932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8900238,"threshold_uncertainty_score":0.426999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08060577922781918,"score_gpt":0.2904639652603926,"score_spread":0.2098581860325734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}