{"id":"W4225939416","doi":"10.1172/jci154891","title":"Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Health and Medical Research Council; National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; Loxo Oncology; National Institutes of Health; Weill Cornell Medical College; McGill University; University of Sydney; National Centre for Supercomputing Applications; Eli Lilly and Company","keywords":"Glutamate receptor; Chloride channel; Ataxia; Neurotoxicity; Excitatory postsynaptic potential; Biology; Cell biology; Mutation; Neuroscience; Chemistry; Biochemistry; Inhibitory postsynaptic potential; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009039419,0.0004477521,0.0002418002,0.0002044126,0.0001985422,0.0001793582,0.0001556041,0.0005447782,0.001728113],"category_scores_gemma":[0.0002020566,0.00007038537,0.0003315238,0.0001972883,0.0003312199,0.000144128,0.0001718678,0.0003290906,0.0002596148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577071,"about_ca_system_score_gemma":0.0002368151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002910606,"about_ca_topic_score_gemma":0.003796576,"domain_scores_codex":[0.9998956,0.00001699127,0.00001819091,0.00002316674,0.00002751318,0.00001844407],"domain_scores_gemma":[0.999903,0.00001978582,0.00003074815,0.000006105493,0.0000118231,0.00002853378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001718899,0.00002677678,0.00143269,0.00002609665,0.00001438544,0.00148728,0.00003822893,0.0001420839,0.9952961,0.0001016726,0.00006407656,0.001198774],"study_design_scores_gemma":[0.000093619,0.0007968391,0.09490321,0.00003186509,0.0001365291,0.01530644,0.0001759424,0.003279295,0.8796052,0.0003467174,0.005287865,0.00003639395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997712,0.0004217537,0.0007033517,0.00008323206,0.00001777595,0.00001156692,0.0003694855,0.00004781689,0.0006331225],"genre_scores_gemma":[0.9985281,0.0002257932,0.0004933408,0.0000493999,0.000004655449,0.000005408327,0.0001843108,0.00001977162,0.00048923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002910606,"threshold_uncertainty_score":0.005787373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2033842251556296,"score_gpt":0.4276291718869455,"score_spread":0.2242449467313159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}