{"id":"W4225972012","doi":"10.7554/elife.72579","title":"Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Institutes of Health; Cancer Research UK; Wallace H. Coulter Foundation","keywords":"Inflammation; Endothelial dysfunction; Cell adhesion molecule; Cell biology; Endothelial activation; Biology; Endothelial stem cell; Endothelium; Chemistry; Cancer research; Immunology; In vitro; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347019,0.00006800503,0.00008142473,0.0000206898,0.0001027674,0.00000619092,0.0000647851,0.00004243475,0.00008971096],"category_scores_gemma":[0.00001422197,0.00006584053,0.00004123562,0.00004355892,0.00001679832,0.000003016875,0.0001568959,0.00003641385,0.000001289701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009576508,"about_ca_system_score_gemma":0.00003575192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001716606,"about_ca_topic_score_gemma":0.000003407453,"domain_scores_codex":[0.9994245,0.00004258243,0.0001313643,0.0001588749,0.0001449127,0.00009774853],"domain_scores_gemma":[0.9997208,0.000005159292,0.00007228198,0.0001343481,0.00003592506,0.00003150788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004452964,0.00001616371,0.001745438,0.000007641985,0.000007646803,1.018422e-7,0.00008863126,0.0001129955,0.9933827,0.00001212681,0.0007649824,0.003817048],"study_design_scores_gemma":[0.0003410935,0.0001350822,0.001277832,0.000007062358,0.000005413075,0.000001276576,0.00007826371,0.00008729596,0.9691792,0.000004538426,0.02880786,0.0000750379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986364,0.0005298979,0.0003184307,0.00003708189,0.00008598613,0.00008912942,0.00004690636,0.000005622677,0.0002505256],"genre_scores_gemma":[0.9986258,0.0002083922,0.0005776204,0.00007416163,0.0001689,0.00004102609,0.00004239511,0.00001304936,0.0002486226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02804288,"threshold_uncertainty_score":0.2684899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570118690756066,"score_gpt":0.2383280088272264,"score_spread":0.2226268219196657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}