{"id":"W4225977271","doi":"10.4049/jimmunol.2100194","title":"Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8+ T Cells in Elderly Humans","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Università degli Studi di Ferrara; Campus France; Università degli Studi di Padova; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Università Italo Francese; Institut Necker-Enfants Malades; Wellcome Trust","keywords":"Naive T cell; Immune system; Lipid metabolism; CD8; Biology; Immunology; Cytotoxic T cell; Immunity; T cell; Homeostasis; Basal (medicine); T-cell receptor; Cell biology; Endocrinology; Diabetes mellitus; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001697594,0.0003522219,0.0003894707,0.0004646367,0.0002387929,0.0002827737,0.0001201706,0.0003081262,0.0008845048],"category_scores_gemma":[0.0002479656,0.0001643614,0.0001332567,0.0002148898,0.0002148081,0.0002233154,0.0001889231,0.0002828219,0.0002039354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001205129,"about_ca_system_score_gemma":0.00007749013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005450646,"about_ca_topic_score_gemma":0.0004203958,"domain_scores_codex":[0.9999421,0.00001050882,0.000008897675,0.00001835819,0.000007941017,0.00001214275],"domain_scores_gemma":[0.999876,0.00001058338,0.00005744936,0.0000137375,0.00001570719,0.00002645221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007387759,0.0003759335,0.6162593,0.0002203279,0.000240407,0.00547955,0.0005416775,0.0003266272,0.3352676,0.0002981947,0.0008136216,0.03278906],"study_design_scores_gemma":[0.00004278646,0.001336327,0.9799153,0.00002707923,0.0001503906,0.005803638,0.000220738,0.00049433,0.01027596,0.000318472,0.001401112,0.00001381587],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983292,0.0007271644,0.0003306685,0.00003608519,0.000008519512,0.000007829822,0.0001334379,0.00001432302,0.0004127554],"genre_scores_gemma":[0.9993864,0.0001567853,0.0001172576,0.0000427511,0.00001280706,0.000005406449,0.00008840934,0.000002878758,0.0001873554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008845048,"threshold_uncertainty_score":0.002958953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428280249126294,"score_gpt":0.2244211345749105,"score_spread":0.2101383320836476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}