{"id":"W4225993798","doi":"10.1016/j.celrep.2021.110190","title":"Integrative clinical and molecular characterization of translocation renal cell carcinoma","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; William Osler Health System","funders":"Janssen Pharmaceuticals; National Cancer Institute; EMD Serono; Genentech; National Institutes of Health; Eisai; Ipsen Biopharmaceuticals; Damon Runyon Cancer Research Foundation; Exelixis; Bayer Fund; National Cancer Center; Takeda Pharmaceuticals U.S.A.; Harvard Medical School; Novartis; Bristol-Myers Squibb; Dana-Farber/Harvard Cancer Center; Merck; GlaxoSmithKline; Pfizer; Rally Foundation; Conquer Cancer Foundation; Doris Duke Charitable Foundation; American Association for Cancer Research; AstraZeneca; Roche; Astellas Pharma US","keywords":"Chromosomal translocation; Renal cell carcinoma; Biology; Cancer research; Kidney cancer; Somatic cell; CD8; Chromosome; Immune checkpoint; Gene; Immune system; Immunology; Pathology; Medicine; Immunotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003370312,0.0001282329,0.0003111243,0.00008605181,0.00005558048,0.000005274355,0.00003021737,0.00004951508,0.0001227285],"category_scores_gemma":[0.00001692439,0.0001117616,0.0001184586,0.0001260886,0.00007585515,0.00003612593,0.00003895388,0.0001897908,0.000001420918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006089948,"about_ca_system_score_gemma":0.0001684378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002820739,"about_ca_topic_score_gemma":6.845522e-7,"domain_scores_codex":[0.9985209,0.0001239315,0.0006068333,0.0003345484,0.0002975578,0.000116263],"domain_scores_gemma":[0.9991159,0.00002595509,0.000339715,0.0003112014,0.00009936144,0.0001078136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001678528,0.0004318833,0.07596863,0.0001049083,0.00002193057,0.001899733,0.0006965034,0.000004975631,0.9182732,0.00001363659,0.0001047255,0.00231199],"study_design_scores_gemma":[0.0008001308,0.001023476,0.1352473,0.00001855797,0.0001600246,0.0004194572,0.0001786585,0.0001031336,0.8603224,0.00004884653,0.00157656,0.0001014472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950933,0.0005632017,0.0005855351,0.0001572305,0.0001757562,0.0005015797,0.000006305124,0.00001669407,0.002900402],"genre_scores_gemma":[0.9980344,0.0000339954,0.0002991912,0.00009191784,0.00003467296,0.00005037419,0.0002811252,0.00002014347,0.001154142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05927867,"threshold_uncertainty_score":0.4557508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883969756822353,"score_gpt":0.2668425912613127,"score_spread":0.2480028936930891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}