{"id":"W4225993798","doi":"10.1016/j.celrep.2021.110190","title":"Integrative clinical and molecular characterization of translocation renal cell carcinoma","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; William Osler Health System","funders":"Janssen Pharmaceuticals; National Cancer Institute; EMD Serono; Genentech; National Institutes of Health; Eisai; Ipsen Biopharmaceuticals; Damon Runyon Cancer Research Foundation; Exelixis; Bayer Fund; National Cancer Center; Takeda Pharmaceuticals U.S.A.; Harvard Medical School; Novartis; Bristol-Myers Squibb; Dana-Farber/Harvard Cancer Center; Merck; GlaxoSmithKline; Pfizer; Rally Foundation; Conquer Cancer Foundation; Doris Duke Charitable Foundation; American Association for Cancer Research; AstraZeneca; Roche; Astellas Pharma US","keywords":"Chromosomal translocation; Renal cell carcinoma; Biology; Cancer research; Kidney cancer; Somatic cell; CD8; Chromosome; Immune checkpoint; Gene; Immune system; Immunology; Pathology; Medicine; Immunotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006419111,0.0002203448,0.000301042,0.0009985018,0.0003148063,0.0008092353,0.0004091162,0.0004029628,0.002116273],"category_scores_gemma":[0.0006987013,0.0001095517,0.0001700344,0.0005787346,0.0004054638,0.0004622721,0.0004262347,0.0005037286,0.0003391669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004968288,"about_ca_system_score_gemma":0.0007596887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069077,"about_ca_topic_score_gemma":0.001512688,"domain_scores_codex":[0.9996718,0.00007245214,0.00003750077,0.00006738786,0.00008349495,0.00006725112],"domain_scores_gemma":[0.9996448,0.00006328293,0.00007030253,0.00004902556,0.0001063371,0.00006631032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001822614,0.0004637773,0.3445958,0.0004883082,0.0001270844,0.005483502,0.0009132844,0.001410464,0.4961374,0.006609126,0.003530945,0.1384178],"study_design_scores_gemma":[0.0003334375,0.002206501,0.7009409,0.0001246116,0.0003346518,0.06827005,0.003303677,0.009848858,0.1379593,0.006589748,0.07002176,0.00006650623],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781723,0.004501109,0.003096923,0.0006137238,0.0000544278,0.0001360716,0.0006259212,0.00007679899,0.01272273],"genre_scores_gemma":[0.9963821,0.0006196303,0.001589034,0.0001002861,0.00004130229,0.00003378941,0.0005209408,0.000008195588,0.0007047229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002116273,"threshold_uncertainty_score":0.007079601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883969756822353,"score_gpt":0.2668425912613127,"score_spread":0.2480028936930891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}