{"id":"W4226000077","doi":"10.1007/s40120-022-00343-x","title":"Pharmacokinetics of XEN496, a Novel Pediatric Formulation of Ezogabine, Under Fed and Fasted Conditions: A Phase 1 Trial","year":2022,"lang":"en","type":"article","venue":"Neurology and Therapy","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Pharmacokinetics; Medicine; Neurology; Pharmacology; Phase (matter); Internal medicine; Chemistry; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009148634,0.0009031994,0.001418207,0.0002142488,0.0002538556,0.0005375348,0.0005068127,0.0009181529,0.001995833],"category_scores_gemma":[0.0008396839,0.0003911047,0.0006071071,0.0002253858,0.0006271498,0.0008569901,0.0001852298,0.00177439,0.0003633567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005027151,"about_ca_system_score_gemma":0.000743372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004402435,"about_ca_topic_score_gemma":0.0007423954,"domain_scores_codex":[0.999716,0.0001453133,0.00001436701,0.00005119276,0.00003663977,0.00003648064],"domain_scores_gemma":[0.9996717,0.00007166227,0.00009493048,0.00002825803,0.00003185369,0.000101547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7629693,0.04666808,0.003378148,0.0008648323,0.0008078648,0.0003451649,0.0002448048,0.001878039,0.08495838,0.0003675106,0.001772071,0.09574576],"study_design_scores_gemma":[0.2077805,0.7642366,0.01157767,0.00003698533,0.0003748429,0.0004628722,0.00006821775,0.002136875,0.01042944,0.0001585718,0.00269534,0.00004207137],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962267,0.00142088,0.0005706669,0.0001143653,0.00004561927,0.0006603593,0.0004177008,0.00006356106,0.0004802709],"genre_scores_gemma":[0.9927655,0.002220055,0.001785115,0.0003077883,0.0001036513,0.0008674944,0.0009441336,0.00003034557,0.0009759046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001995833,"threshold_uncertainty_score":0.006676733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08842120990572219,"score_gpt":0.4061781007746421,"score_spread":0.3177568908689199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}