{"id":"W4226003869","doi":"10.1093/jnci/djac094","title":"Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk","year":2022,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; NIHR Imperial Biomedical Research Centre; National Health and Medical Research Council; World Cancer Research Fund; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; Office of Research Infrastructure Programs, National Institutes of Health; Junta de Castilla y León; Institut Gustave-Roussy; Cancer Council Victoria; Deutsche Krebshilfe; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Universitat de Barcelona; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Umeå Universitet; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Swedish Cancer Foundation; Bundesministerium für Bildung und Forschung; Canadian Cancer Society Research Institute; McGill University; University of Leeds; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Fred Hutchinson Cancer Research Center; Associazione Italiana per la Ricerca sul Cancro; Imperial College London; Damon Runyon Cancer Research Foundation; Génome Québec; World Health Organization; Cancer Research UK; U.S. Department of Health and Human Services","keywords":"Odds ratio; Medicine; Internal medicine; Progestogen; Oncology; Colorectal cancer; Single-nucleotide polymorphism; Confidence interval; Hormone therapy; Estrogen; Genotype; Genome-wide association study; Gynecology; Cancer; Breast cancer; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002441955,0.0004648307,0.000796234,0.0009326892,0.0003196506,0.0005882257,0.0005114622,0.0005077687,0.002315337],"category_scores_gemma":[0.004398262,0.0002009582,0.00327095,0.001337154,0.0003236888,0.0001789845,0.0004233965,0.0006328645,0.0001216044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002492865,"about_ca_system_score_gemma":0.0004285692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00318067,"about_ca_topic_score_gemma":0.005034313,"domain_scores_codex":[0.9976121,0.001331851,0.0001692964,0.0005284587,0.0002197939,0.0001384384],"domain_scores_gemma":[0.9943505,0.003647393,0.001144493,0.0004173045,0.0001589149,0.0002814287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004205619,0.00005295608,0.971834,0.0001955173,0.01372632,0.0003089907,0.00009580132,0.000586429,0.004154068,0.0000797855,0.0002119197,0.004548576],"study_design_scores_gemma":[0.000131811,0.0004909839,0.9902041,0.00002102997,0.006198881,0.0003973859,0.00006456851,0.001253523,0.0005388235,0.0001802639,0.0005042801,0.00001430573],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940929,0.003310861,0.000919698,0.0001857027,0.00003223935,0.00001595944,0.001025009,0.00003231313,0.0003853872],"genre_scores_gemma":[0.998855,0.0001874765,0.0005210623,0.00004585147,0.00001486905,0.00001780063,0.0002573899,0.000007376547,0.00009311061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00318067,"threshold_uncertainty_score":0.01291448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05019864349174261,"score_gpt":0.3641204900489701,"score_spread":0.3139218465572275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}