{"id":"W4226021801","doi":"10.1093/ecco-jcc/jjac045","title":"Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Crohn's and Colitis Foundation","keywords":"Medicine; Inflammatory bowel disease; Disease; Cohort; Proband; Exome sequencing; Pediatrics; Internal medicine; OMIM : Online Mendelian Inheritance in Man; Age of onset; Phenotype; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007596362,0.0002585016,0.000367802,0.0006938266,0.0004669408,0.0006193949,0.000375825,0.0004526191,0.001096074],"category_scores_gemma":[0.003146069,0.0001427168,0.0003280375,0.0007463312,0.0003477288,0.000509057,0.0007666298,0.0003855007,0.0001530613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000252238,"about_ca_system_score_gemma":0.0001645064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005850139,"about_ca_topic_score_gemma":0.0008149745,"domain_scores_codex":[0.9994885,0.0001220752,0.00007494564,0.0001595288,0.0000565412,0.00009835319],"domain_scores_gemma":[0.997363,0.0005210808,0.001414146,0.00013872,0.000130518,0.0004325328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002780539,0.00001622708,0.9981486,0.00001052827,0.00002731947,0.0002770919,0.00004694311,0.00004703574,0.0002760787,0.00001515274,0.0000373936,0.0008196213],"study_design_scores_gemma":[0.000010758,0.0001436144,0.9976503,0.000009991607,0.00002122901,0.00175397,0.0001142636,0.0001200817,0.0000631138,0.00003937796,0.000069933,0.000003313944],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995046,0.0001561839,0.00004726311,0.00001249139,0.000002171475,0.000003043986,0.0001510438,0.000001398255,0.0001218732],"genre_scores_gemma":[0.9995584,0.00003647231,0.00004088875,0.00001172338,0.000004924528,0.000004517691,0.0003148204,9.911223e-7,0.0000273002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096074,"threshold_uncertainty_score":0.004017353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009291132271220002,"score_gpt":0.2671651572755582,"score_spread":0.2578740250043382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}