{"id":"W4226021801","doi":"10.1093/ecco-jcc/jjac045","title":"Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Crohn's and Colitis Foundation","keywords":"Medicine; Inflammatory bowel disease; Disease; Cohort; Proband; Exome sequencing; Pediatrics; Internal medicine; OMIM : Online Mendelian Inheritance in Man; Age of onset; Phenotype; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005594405,0.0001530146,0.000239512,0.00009072226,0.0001478094,0.00004278491,0.0001706762,0.00007030118,0.00003769627],"category_scores_gemma":[0.0001523481,0.0001518394,0.0001875549,0.00004113049,0.0001277183,0.00001809102,0.0002275389,0.0002834131,0.000001802336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003314259,"about_ca_system_score_gemma":0.0003429126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001160649,"about_ca_topic_score_gemma":0.0000412786,"domain_scores_codex":[0.9985625,0.0002273511,0.0005534836,0.0002182723,0.0002076185,0.0002307762],"domain_scores_gemma":[0.9990975,0.00006092379,0.0002494928,0.0002016937,0.00006836772,0.0003220664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02052698,0.0001670222,0.9738232,0.00003645692,0.0002050349,0.001658714,0.0001174589,0.00005161292,0.0001246236,0.00004809476,0.0008034178,0.002437375],"study_design_scores_gemma":[0.002877241,0.0004045874,0.9936036,0.00001402679,0.00007343869,0.00003682651,0.000150218,0.00003229825,0.00003479445,0.0001624274,0.002438745,0.000171736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974243,0.001753062,0.000005214365,0.000107074,0.0004163514,0.0001444677,0.00007689962,0.000003061715,0.00006956339],"genre_scores_gemma":[0.998637,0.0006900115,0.00005517674,0.0002403897,0.0001887666,0.00001783494,0.000008326677,0.00001968881,0.0001427751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01978046,"threshold_uncertainty_score":0.619183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009291132271220002,"score_gpt":0.2671651572755582,"score_spread":0.2578740250043382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}