{"id":"W4226022053","doi":"10.1016/j.clml.2021.12.003","title":"An Overview of CAR T Cell Mediated B Cell Maturation Antigen Therapy","year":2021,"lang":"en","type":"review","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Chimeric antigen receptor; Multiple myeloma; Medicine; Malignancy; Plasma cell; Antigen; Cancer research; Antibody; Clinical trial; Cancer; Immunology; Oncology; Immunotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008530461,0.001088317,0.00188495,0.002411729,0.0002638164,0.001282655,0.001145397,0.001300656,0.004586591],"category_scores_gemma":[0.0007389914,0.0004026779,0.0008223084,0.002194979,0.0004500429,0.001313073,0.000718245,0.002637008,0.002378976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008917515,"about_ca_system_score_gemma":0.001308043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285081,"about_ca_topic_score_gemma":0.002620984,"domain_scores_codex":[0.9997926,0.000043003,0.00002676766,0.00004003606,0.00006491296,0.00003262006],"domain_scores_gemma":[0.9996945,0.0001651846,0.00003747588,0.000008053398,0.00006412606,0.00003073752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001720375,0.0001663079,0.000114976,0.01939608,0.0001238917,0.0001558966,0.00003177549,0.0005563181,0.002174562,0.003822144,0.04477119,0.9285147],"study_design_scores_gemma":[0.00009177069,0.0003442136,0.0004184077,0.003610188,0.0002179021,0.000732441,0.00002588018,0.0001819833,0.0006496839,0.001159237,0.9925487,0.00001958425],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007941661,0.9985663,0.0001698764,0.0002084611,0.0001896327,0.000008834171,0.00002431208,0.000009258468,0.0007438842],"genre_scores_gemma":[0.0005529131,0.9980433,0.0002696202,0.0003189772,0.0001873833,0.00001314996,0.00005101824,0.000002029068,0.0005615024],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004586591,"threshold_uncertainty_score":0.01534361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1708511973895735,"score_gpt":0.4525105370994986,"score_spread":0.2816593397099251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}