{"id":"W4226022053","doi":"10.1016/j.clml.2021.12.003","title":"An Overview of CAR T Cell Mediated B Cell Maturation Antigen Therapy","year":2021,"lang":"en","type":"review","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Chimeric antigen receptor; Multiple myeloma; Medicine; Malignancy; Plasma cell; Antigen; Cancer research; Antibody; Clinical trial; Cancer; Immunology; Oncology; Immunotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002381755,0.001072942,0.006511242,0.0004016286,0.0001141614,0.00009892142,0.001033604,0.00224163,0.004283728],"category_scores_gemma":[0.00046682,0.0008584643,0.00295525,0.001436586,0.0004787234,0.0001706996,0.0002369031,0.001234147,0.0005044041],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001310487,"about_ca_system_score_gemma":0.00952791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001247237,"about_ca_topic_score_gemma":0.000008006579,"domain_scores_codex":[0.989993,0.002312588,0.003718234,0.001657133,0.001413701,0.0009052983],"domain_scores_gemma":[0.9916521,0.002346402,0.001471654,0.002885298,0.000735286,0.0009092683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003215552,0.0008090205,0.0001222271,0.01113911,0.000462887,0.0004533564,0.00006405373,3.023061e-7,0.00114315,0.00002000677,0.002119622,0.9833447],"study_design_scores_gemma":[0.003729234,0.001281242,0.005669919,0.007984215,0.0007671512,0.0001561983,0.0000362473,0.0000532754,0.0008729284,0.0000145504,0.9786893,0.0007457683],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01326872,0.9796699,0.000006876543,0.0000385366,0.0008013127,0.002327001,0.0001652956,0.0001539654,0.00356834],"genre_scores_gemma":[0.0004565073,0.9900277,0.0004357914,0.0004120301,0.00151131,0.0001274255,0.003101722,0.0003397226,0.003587804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.982599,"threshold_uncertainty_score":0.9993866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1708511973895735,"score_gpt":0.4525105370994986,"score_spread":0.2816593397099251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}