{"id":"W4226022552","doi":"10.2139/ssrn.4079234","title":"Implementation of Analytical Quality by Design and Green Chemistry Principles to Develop a Novel UPLC Method for the Determination of Fluocinolone Acetonide Impurities from its Drug Substance and Topical Oil Formulations","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas College","funders":"","keywords":"Fluocinolone acetonide; Chemistry; Chromatography; High-performance liquid chromatography; Drug; Pharmacology; Medicine; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003646048,0.0008218571,0.0007440045,0.0007488018,0.0006220437,0.001293149,0.0009936932,0.001183377,0.001075299],"category_scores_gemma":[0.001907218,0.000570034,0.001025311,0.0003799312,0.0009852105,0.0007620974,0.001213471,0.001954881,0.000767849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001177723,"about_ca_system_score_gemma":0.003305169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001754816,"about_ca_topic_score_gemma":0.003797113,"domain_scores_codex":[0.9971373,0.0004425176,0.0001234604,0.0004263562,0.001682643,0.000187613],"domain_scores_gemma":[0.99893,0.0002319106,0.0001782992,0.0001175203,0.0004901483,0.0000521172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008371483,0.0002590083,0.0006790104,0.0001957099,0.00006110262,0.0001186207,0.00005874035,0.003171595,0.948078,0.004895782,0.000615464,0.04178311],"study_design_scores_gemma":[0.00003586851,0.0003550619,0.0007098975,0.00001780482,0.00003991211,0.0002179609,0.00001950059,0.04537732,0.9442798,0.00100913,0.00788621,0.00005138436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04212524,0.0006107329,0.9523063,0.0004710747,0.0001141343,0.0006592093,0.0001434257,0.001223558,0.002346395],"genre_scores_gemma":[0.1847246,0.0006084273,0.8095244,0.0006797408,0.00004324401,0.0006008079,0.0002992052,0.000201039,0.003318559],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003646048,"threshold_uncertainty_score":0.01928234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07768323789349629,"score_gpt":0.4160914555612947,"score_spread":0.3384082176677984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}