{"id":"W4226024384","doi":"10.2139/ssrn.4065397","title":"HER2 Testing in Metastatic Breast Cancer – Is Reflex ISH Testing Necessary on HER2 IHC-Equivocal (2+) Cases?","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; Nova Scotia Health Authority","funders":"","keywords":"Medicine; Metastatic breast cancer; Immunohistochemistry; Cancer; Breast cancer; Reflex; Pathology; Male breast cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002633455,0.0005246946,0.0008294209,0.001272777,0.000427455,0.001277124,0.00116186,0.001762457,0.003758043],"category_scores_gemma":[0.01037083,0.0003701587,0.0005748026,0.0009673864,0.001284937,0.001908645,0.0005011585,0.001197577,0.002079039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004430385,"about_ca_system_score_gemma":0.0006783857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001483577,"about_ca_topic_score_gemma":0.002373083,"domain_scores_codex":[0.9988192,0.0003173017,0.0002556957,0.0001614721,0.0002471728,0.0001991518],"domain_scores_gemma":[0.9964687,0.001746856,0.0004289747,0.0002502385,0.0006102404,0.0004951104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002708774,0.0002221021,0.7644625,0.0007002812,0.0001476709,0.02284832,0.0005499459,0.0009814417,0.01160943,0.001259666,0.01332952,0.1811802],"study_design_scores_gemma":[0.000308473,0.002747315,0.7092831,0.002875352,0.0007160628,0.1743685,0.006442765,0.007592482,0.01733659,0.0142545,0.06388175,0.00019311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8657775,0.0526429,0.006733608,0.02554126,0.001843631,0.0001179978,0.0008743499,0.0004174691,0.04605129],"genre_scores_gemma":[0.9797509,0.01020131,0.003936993,0.003047123,0.00128322,0.00003227718,0.0005459886,0.00006688134,0.00113524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003758043,"threshold_uncertainty_score":0.01392722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0668902302484689,"score_gpt":0.3748583454654088,"score_spread":0.3079681152169399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}