{"id":"W4226028006","doi":"10.1016/j.healun.2022.01.263","title":"Efficacy and Safety of the Janus Kinase 1 Inhibitor Itacitinib (ITA) in Patients with Bronchiolitis Obliterans (BOS) Syndrome Following Double Lung Transplant","year":2022,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Duke Clinical Research Institute; School of Medicine, Duke University; KU Leuven; University of California, Los Angeles; Incyte; Temple University; University of Pennsylvania; Cleveland Clinic; University of Pittsburgh","keywords":"Medicine; Bronchiolitis obliterans; Internal medicine; Lung transplantation; Adverse effect; Gastroenterology; Transplantation; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008343697,0.0002990949,0.001146483,0.0002628431,0.0003256823,0.0008798598,0.0002368122,0.0004346767,0.0008831645],"category_scores_gemma":[0.001402607,0.000127978,0.0009961729,0.0002956334,0.0003624506,0.0006862397,0.0002353725,0.001283542,0.0001523463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005634028,"about_ca_system_score_gemma":0.0005286227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003679414,"about_ca_topic_score_gemma":0.0007407573,"domain_scores_codex":[0.9996562,0.00008670729,0.00005258632,0.00005477381,0.00005561117,0.00009413755],"domain_scores_gemma":[0.9992363,0.0001935415,0.0002806206,0.00004540317,0.00006247075,0.0001816207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2996073,0.006307555,0.380149,0.001246119,0.003282591,0.001460952,0.0003171008,0.002021597,0.01461702,0.0005141745,0.001952062,0.2885246],"study_design_scores_gemma":[0.02816426,0.1324574,0.8136168,0.000391483,0.005701331,0.003422478,0.0005640473,0.003863006,0.006678614,0.0007313979,0.004300387,0.0001088645],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955871,0.003409658,0.00008200385,0.0001721279,0.00005439874,0.00002592524,0.00009213576,0.000006128444,0.0005705938],"genre_scores_gemma":[0.9988133,0.0006142489,0.00006231206,0.0001132276,0.00007466467,0.00001855497,0.0001832138,0.000001186313,0.0001193359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146483,"threshold_uncertainty_score":0.004412651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008284835298152564,"score_gpt":0.2550638394476019,"score_spread":0.2467790041494493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}