{"id":"W4226029235","doi":"10.1002/ange.202114858","title":"The Chiral Target of Daptomycin Is the 2<i>R</i>,2′<i>S</i> Stereoisomer of Phosphatidylglycerol","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphatidylglycerol; Daptomycin; Stereochemistry; Enantiopure drug; Chemistry; Liposome; Enantiomer; Lipopeptide; Membrane; Phospholipid; Biochemistry; Phosphatidylcholine; Biology; Bacteria; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009312284,0.0002543351,0.0001602562,0.0001175618,0.0001303729,0.0002715147,0.0001198776,0.0001842682,0.001118374],"category_scores_gemma":[0.0001117267,0.00007727672,0.0001135337,0.00008809241,0.0001849633,0.0001124785,0.0001568374,0.0003412453,0.0004504189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686926,"about_ca_system_score_gemma":0.0001801365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003311331,"about_ca_topic_score_gemma":0.0002948146,"domain_scores_codex":[0.9999084,0.00001759407,0.000005253839,0.00002209029,0.00002207086,0.00002457504],"domain_scores_gemma":[0.9999262,0.00001286482,0.00001981775,0.000007135351,0.000009997672,0.00002395944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003724442,0.000006404906,0.00009679078,0.000009354691,9.433399e-7,0.00002934594,0.000003014016,0.00002953782,0.9988213,0.000121328,0.00001807132,0.000826572],"study_design_scores_gemma":[0.000003325268,0.00006926795,0.0005050795,0.000001428665,0.000001549478,0.0000846365,0.000006588753,0.0001822741,0.9982772,0.0000266957,0.0008404187,0.000001502931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861481,0.0008910085,0.005562671,0.0001332108,0.00005559347,0.00003562576,0.0002078874,0.00007891779,0.006886862],"genre_scores_gemma":[0.9957494,0.0002616059,0.002342124,0.00006090481,0.000006242501,0.000008531201,0.0001317668,0.00001406732,0.001425428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118374,"threshold_uncertainty_score":0.003741264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104808762961709,"score_gpt":0.2190713434335333,"score_spread":0.2085904671373624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}