{"id":"W4226040711","doi":"10.2139/ssrn.4052958","title":"NAD Depletion Mediates Cytotoxicity in Human Neurons With Autophagy Deficiency","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"","keywords":"NAD+ kinase; Cytotoxicity; Autophagy; Chemistry; Cell biology; Programmed cell death; Apoptosis; Biology; Biochemistry; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740517,0.0003157694,0.0005751111,0.0002672745,0.000254021,0.0004448977,0.0003711977,0.0004744131,0.002727464],"category_scores_gemma":[0.0001509225,0.0001778312,0.0005820062,0.0003812403,0.0002896368,0.0002590365,0.00026408,0.000783406,0.0008125838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003869184,"about_ca_system_score_gemma":0.0004520467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002442206,"about_ca_topic_score_gemma":0.002883889,"domain_scores_codex":[0.9998288,0.0000271769,0.00002598506,0.00003148075,0.00003421939,0.00005229002],"domain_scores_gemma":[0.9999347,0.00000917507,0.00001305338,0.00001515191,0.00001459036,0.00001329337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00399232,0.0003381624,0.001990649,0.0002144248,0.0001184677,0.001264581,0.000136722,0.000169528,0.9850008,0.0003208559,0.0005051407,0.00594829],"study_design_scores_gemma":[0.0002104705,0.002320506,0.02221426,0.00003836789,0.0002557314,0.002217893,0.0006034006,0.001123262,0.9659164,0.0002904958,0.00478948,0.00001970844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934622,0.002368333,0.0006954561,0.0001610037,0.0001019404,0.0000235947,0.0006175083,0.00006843368,0.002501576],"genre_scores_gemma":[0.9959158,0.00108954,0.0003177456,0.00004816351,0.00000952263,0.00002281684,0.0006194923,0.000008220709,0.001968832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002727464,"threshold_uncertainty_score":0.009124339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00754627314038882,"score_gpt":0.2502592378799314,"score_spread":0.2427129647395426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}