{"id":"W4226042249","doi":"10.7759/cureus.21021","title":"Intestinal Stem Cell Marker ASCL2 is a Novel Prognostic Predictor in Esophageal Adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Cureus","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"LGR5; Medicine; Tissue microarray; Stem cell marker; Stem cell; Immunohistochemistry; Pathology; Adenocarcinoma; Esophagus; Internal medicine; Oncology; Cancer research; Cancer stem cell; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045614,0.0003208004,0.0003151384,0.0007457202,0.0002030865,0.0004282323,0.0001757136,0.0003237638,0.0008701978],"category_scores_gemma":[0.0008242516,0.0001277028,0.0001806324,0.000642522,0.0002640669,0.0002620336,0.0002701096,0.0002299847,0.0002162399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910136,"about_ca_system_score_gemma":0.0001307946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004558353,"about_ca_topic_score_gemma":0.0009228482,"domain_scores_codex":[0.9998609,0.00003061986,0.00001783664,0.00003207992,0.00003610868,0.00002240648],"domain_scores_gemma":[0.9996643,0.00006800202,0.0001240097,0.00002116683,0.00004672186,0.00007580193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005799548,0.0000201377,0.9856324,0.0000243512,0.00002904474,0.0001981483,0.00002111495,0.0001846845,0.007443931,0.00001591487,0.0001449676,0.005705196],"study_design_scores_gemma":[0.00001977323,0.0002165548,0.9903715,0.000008458449,0.0001024773,0.001346509,0.00009340429,0.003886623,0.003191014,0.00008855072,0.0006689793,0.000006208929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982731,0.0008397835,0.0004222206,0.00004481202,0.000006644058,0.000006712875,0.0001354884,0.00001567615,0.0002556268],"genre_scores_gemma":[0.9992687,0.0001156673,0.0002816343,0.000009584102,0.00001518041,0.000005935562,0.00018061,0.000001374012,0.000121419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008701978,"threshold_uncertainty_score":0.002911091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297825080234755,"score_gpt":0.2848611889706166,"score_spread":0.2550786809471411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}