{"id":"W4226052234","doi":"10.1136/gutjnl-2021-326259","title":"CXCR2 inhibition enables NASH-HCC immunotherapy","year":2022,"lang":"en","type":"article","venue":"Gut","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Institute of Cancer Research","funders":"European Social Fund; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; Medical Research Council; Genentech; National Institutes of Health; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; Agència de Gestió d'Ajuts Universitaris i de Recerca; Associazione Italiana per la Ricerca sul Cancro; Eisai; Ministerio de Ciencia e Innovación; Fundación Científica Asociación Española Contra el Cáncer; Generalitat de Catalunya; Exelixis; Bayer HealthCare; Cancer Research UK; Wellcome Trust; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Deutsche Forschungsgemeinschaft; Ipsen; Samuel Waxman Cancer Research Foundation","keywords":"Cancer research; Immunotherapy; CXC chemokine receptors; CD8; Immunology; Granzyme B; Cytotoxic T cell; Biology; Tumor microenvironment; Immune system; Medicine; Chemokine; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715416,0.0002530796,0.0002931575,0.0001302209,0.0001264414,0.0003485639,0.0001417332,0.0002339033,0.003323246],"category_scores_gemma":[0.00009346374,0.00009434927,0.0002361907,0.00008640443,0.0001671396,0.0001736594,0.0002113128,0.0007659562,0.0006221158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656643,"about_ca_system_score_gemma":0.0002486297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004301202,"about_ca_topic_score_gemma":0.0008309916,"domain_scores_codex":[0.999856,0.00002344451,0.000008362218,0.00002732682,0.00003622136,0.00004858755],"domain_scores_gemma":[0.9999608,0.000005602991,0.000009643357,0.000004758871,0.000005225053,0.0000139617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007073633,0.000253666,0.0005596051,0.0002344993,0.0000192569,0.00007373439,0.00002928172,0.0003826748,0.9810148,0.0006494372,0.0007648537,0.0153106],"study_design_scores_gemma":[0.0002314293,0.004849056,0.005511474,0.00003596385,0.00007930635,0.000662892,0.00005547924,0.002753706,0.9606931,0.0002113931,0.02490261,0.00001358683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708459,0.01101747,0.006248645,0.0008919353,0.0002421186,0.0002440878,0.0009894221,0.0005387426,0.008981592],"genre_scores_gemma":[0.9895204,0.002283602,0.002094912,0.0001848052,0.00003165436,0.0001329259,0.0006325484,0.00002100753,0.005098111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003323246,"threshold_uncertainty_score":0.0111174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192174564657224,"score_gpt":0.2461518140211763,"score_spread":0.234230068374604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}