{"id":"W4226056045","doi":"10.1002/ange.202114581","title":"Catalytic DNA Polymerization Can Be Expedited by Active Product Release**","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Army Research Office; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Basic Energy Sciences; American Institute of Physics; U.S. Department of Energy","keywords":"DNA; Base pair; Chemistry; Sequence (biology); Helicase; Branch migration; DNA nanotechnology; A-DNA; Substrate (aquarium); Combinatorial chemistry; Biophysics; Nanotechnology; Materials science; Biology; Biochemistry; DNA repair; Holliday junction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004489231,0.0003839446,0.0002016967,0.0001646277,0.0001791181,0.0005363311,0.0005051146,0.0003717333,0.002362839],"category_scores_gemma":[0.0008337203,0.0002949346,0.000178951,0.0001382255,0.0003882981,0.0005169991,0.0003833747,0.0007201415,0.001019338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001905214,"about_ca_system_score_gemma":0.0001520164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001212587,"about_ca_topic_score_gemma":0.0002191635,"domain_scores_codex":[0.9997193,0.00003761022,0.00001986717,0.0000840509,0.00008883074,0.00005031513],"domain_scores_gemma":[0.999602,0.0001620723,0.00008024584,0.00007064267,0.00003699409,0.00004816447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008585815,0.00005083939,0.000110305,0.00008121555,0.000006152432,0.000076321,0.00002399674,0.0006127716,0.9892435,0.003151251,0.0002896141,0.006268121],"study_design_scores_gemma":[0.00001063062,0.00006860089,0.0001276426,0.000003439945,0.000003063699,0.00005311021,0.000003882031,0.003041106,0.9937645,0.000340853,0.002578889,0.000004264971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8800302,0.001885551,0.09806927,0.0004240782,0.0001825707,0.00009057391,0.000295427,0.001929947,0.0170924],"genre_scores_gemma":[0.9893526,0.0003386369,0.007651943,0.00004198225,0.00001075902,0.00003214298,0.0001260718,0.00007309917,0.002372697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002362839,"threshold_uncertainty_score":0.00790453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008825937159195071,"score_gpt":0.2436785632536389,"score_spread":0.2348526260944439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}