{"id":"W4226057129","doi":"10.1016/j.neuroimage.2022.119220","title":"Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex","year":2022,"lang":"en","type":"article","venue":"NeuroImage","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Queen's University; McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Institute of Health Services and Policy Research; Beckley Foundation; Natural Sciences and Engineering Research Council of Canada; H2020 European Research Council; Canada Research Chairs; Canadian Institutes of Health Research; European Research Council; Alexander Mosley Charitable Trust","keywords":"Psilocybin; Serotonergic; Lysergic acid diethylamide; Hallucinogen; Psychology; Neuroscience; Default mode network; Temporal lobe; Cognitive psychology; Functional connectivity; Biology; Serotonin; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000250276,0.000166171,0.0002310315,0.00008317007,0.0003613966,0.00002869488,0.0001926579,0.00004124825,0.0002005419],"category_scores_gemma":[0.00001096452,0.0001317117,0.00006177268,0.0001992397,0.0002815171,0.00004877017,0.0001484247,0.000388383,0.00000286127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009661146,"about_ca_system_score_gemma":0.00001478432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001168609,"about_ca_topic_score_gemma":0.000009218274,"domain_scores_codex":[0.9984817,0.0003223282,0.0002808588,0.0004196544,0.0002516327,0.0002438269],"domain_scores_gemma":[0.9993093,0.0001625464,0.0001022695,0.0003361354,0.00002648153,0.00006323958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005832813,0.004641842,0.05972051,0.0004409202,0.001252273,0.0001819443,0.1410009,0.000123357,0.3105689,0.2385286,0.03339421,0.2043138],"study_design_scores_gemma":[0.002885401,0.0006395649,0.9770423,0.000008394197,0.00009954962,0.0001183234,0.003939966,0.00123368,0.0003395132,0.007717056,0.005650372,0.0003258948],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870164,0.0007913244,0.00005733629,0.005284495,0.0004559575,0.0003461677,0.0000543652,0.00003329586,0.005960603],"genre_scores_gemma":[0.998767,0.0000914785,0.00003070655,0.0005208806,0.00005911291,0.0001079336,0.00001048592,0.00002389828,0.0003884813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9173218,"threshold_uncertainty_score":0.5371046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513523718568168,"score_gpt":0.3050477906040414,"score_spread":0.2799125534183597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}