{"id":"W4226058556","doi":"10.1016/j.medj.2022.04.002","title":"Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, Beta, Delta, and Omicron variants","year":2022,"lang":"en","type":"article","venue":"Med","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Saskatchewan Health Authority; University Health Network; Saskatchewan Health; University of Toronto; Dalhousie University; Sinai Health System; University of Waterloo; Sunnybrook Health Science Centre; University of Saskatchewan","funders":"Sanofi Pasteur; Moderna; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Innovation Saskatchewan; Janssen Pharmaceuticals; Gilead Sciences; Sanofi; GlaxoSmithKline; Merck; University of Toronto; Pfizer","keywords":"Immunogenicity; Virology; Biology; BETA (programming language); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Delta; Coronavirus disease 2019 (COVID-19); Immunology; Medicine; Antibody; Physics; Infectious disease (medical specialty); Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009269251,0.0001503676,0.0005842099,0.0001184235,0.00008831325,0.00001026563,0.0001545507,0.00009364967,0.00001438734],"category_scores_gemma":[0.0001510569,0.0001372901,0.0001021913,0.0002258713,0.000194597,0.00005600239,0.0002480207,0.0004012132,0.000001880069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005341782,"about_ca_system_score_gemma":0.0002385937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004023909,"about_ca_topic_score_gemma":0.00003621758,"domain_scores_codex":[0.998271,0.0002204367,0.0006039286,0.0003340483,0.0002825501,0.0002880378],"domain_scores_gemma":[0.9991593,0.0001894384,0.0001796781,0.0002971898,0.0001348678,0.0000394806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001596673,0.0003698428,0.3089707,0.0001880014,0.0001697613,0.00003890614,0.0002770426,3.376764e-7,0.683078,0.00001563969,0.000185129,0.005109946],"study_design_scores_gemma":[0.007294188,0.001122453,0.3392725,0.00007471429,0.0001196373,0.00005668486,0.0002472021,0.001339241,0.6466118,0.00004964415,0.003647542,0.0001644367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968115,0.002145201,0.00001226262,0.0002700445,0.000117772,0.0004358179,0.00005882995,0.00002092969,0.0001276457],"genre_scores_gemma":[0.996252,0.0001097319,0.0001120171,0.003436747,0.00003270838,0.00001399999,0.00001226234,0.00001887724,0.00001163134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03646623,"threshold_uncertainty_score":0.5598526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06122530900822045,"score_gpt":0.3704799722747525,"score_spread":0.3092546632665321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}