{"id":"W4226072456","doi":"10.1007/s11883-022-01018-6","title":"Monogenic Versus Polygenic Forms of Hypercholesterolemia and Cardiovascular Risk: Are There Any Differences?","year":2022,"lang":"en","type":"review","venue":"Current Atherosclerosis Reports","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Familial hypercholesterolemia; Medicine; Polygenic risk score; Internal medicine; Angiology; Genotype; Bioinformatics; Genetics; Cholesterol; Single-nucleotide polymorphism; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001601672,0.0008626814,0.003377038,0.001744433,0.0001781274,0.001605227,0.00108108,0.001612886,0.003114597],"category_scores_gemma":[0.001894106,0.0003260348,0.0009768119,0.002643596,0.0008049001,0.001549078,0.0007798464,0.001746829,0.0007632283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003876137,"about_ca_system_score_gemma":0.001287028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285945,"about_ca_topic_score_gemma":0.001911498,"domain_scores_codex":[0.9996169,0.00009885909,0.00008734391,0.00007235901,0.00009458558,0.00002988093],"domain_scores_gemma":[0.9992367,0.0004876917,0.0001272949,0.00001753316,0.00009035808,0.00004033555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007812008,0.0001001381,0.002180127,0.04743632,0.001997529,0.0003172677,0.0001324523,0.00014498,0.0007089003,0.003824535,0.02090738,0.9214692],"study_design_scores_gemma":[0.0008038186,0.0006488517,0.02940657,0.07212678,0.01210472,0.004432786,0.0008767688,0.0002965717,0.0005231391,0.01254944,0.8660834,0.0001471485],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009554581,0.9993207,0.00003083373,0.0003112009,0.0001292885,9.855282e-7,0.000009111929,0.000001118335,0.0001011707],"genre_scores_gemma":[0.0007118474,0.9986256,0.00007274736,0.0002365545,0.0002757362,0.000002688465,0.00001685139,5.212041e-7,0.00005743605],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003377038,"threshold_uncertainty_score":0.01041943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1072667038807617,"score_gpt":0.3233598195180826,"score_spread":0.2160931156373209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}