{"id":"W4226072456","doi":"10.1007/s11883-022-01018-6","title":"Monogenic Versus Polygenic Forms of Hypercholesterolemia and Cardiovascular Risk: Are There Any Differences?","year":2022,"lang":"en","type":"review","venue":"Current Atherosclerosis Reports","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Familial hypercholesterolemia; Medicine; Polygenic risk score; Internal medicine; Angiology; Genotype; Bioinformatics; Genetics; Cholesterol; Single-nucleotide polymorphism; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001734933,0.000908896,0.005072589,0.000280331,0.0002760964,0.00005179049,0.0002740334,0.0004454817,0.0002108105],"category_scores_gemma":[0.0003016782,0.0006702297,0.005150762,0.0005537533,0.000177048,0.0001004164,0.0004227049,0.001393544,0.000007522312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003576849,"about_ca_system_score_gemma":0.0005917163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001478338,"about_ca_topic_score_gemma":0.000008986743,"domain_scores_codex":[0.9941083,0.0005268768,0.001707195,0.001403686,0.001576042,0.0006778654],"domain_scores_gemma":[0.9945294,0.0001331756,0.001786893,0.003002273,0.0001037094,0.0004445935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003222587,0.0001970367,0.009816128,0.01683214,0.004014188,0.00007148296,0.00009158129,6.349844e-7,0.000001075965,0.000002728623,0.00004912482,0.9688916],"study_design_scores_gemma":[0.001245136,0.0003895453,0.02615048,0.01429049,0.01421122,0.0006193255,0.0001336943,0.000001862233,0.000003572941,0.00001214394,0.9422281,0.000714473],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09323595,0.9026729,0.00002158644,0.000003548025,0.001349458,0.002385937,0.0001444525,0.00008629636,0.00009980297],"genre_scores_gemma":[0.03560637,0.962923,0.00003215995,0.000005196677,0.0003829868,0.0006927199,0.0001434539,0.0001845358,0.00002961521],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9681772,"threshold_uncertainty_score":0.9995749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1072667038807617,"score_gpt":0.3233598195180826,"score_spread":0.2160931156373209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}