{"id":"W4226073269","doi":"10.1038/s41467-022-29498-9","title":"ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute; U.S. Department of Health and Human Services; Shear Family Foundation; National Institutes of Health; University of Pittsburgh; U.S. Department of Defense","keywords":"Biology; Estrogen receptor alpha; Cancer research; FOXA1; Estrogen receptor; Immune system; Breast cancer; Paracrine signalling; Receptor; Immunology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188518,0.0001129467,0.0001896815,0.0001082047,0.0006098898,0.00002524239,0.0002717667,0.00008079284,0.0003274178],"category_scores_gemma":[0.00004627064,0.0001110916,0.0000606872,0.0004463914,0.00009062048,0.00008405496,0.0003371136,0.001139285,0.000002324537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003901387,"about_ca_system_score_gemma":0.000286277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000827132,"about_ca_topic_score_gemma":0.0005794597,"domain_scores_codex":[0.9991316,0.000109688,0.000198355,0.0001752244,0.0002311548,0.0001539292],"domain_scores_gemma":[0.9985455,0.00009650367,0.00009996052,0.001051965,0.0001235037,0.00008262173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007903484,0.001013491,0.007614521,0.00009318161,0.0005782222,0.00001329107,0.002345739,0.0001642351,0.8822442,0.01376931,0.02100926,0.07036422],"study_design_scores_gemma":[0.004435481,0.0004317379,0.08516283,0.0001106773,0.0004485718,0.000436042,0.003163748,0.003482746,0.02442664,0.0002067075,0.8771467,0.0005481103],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8469536,0.03048294,0.0001995184,0.09774689,0.0007993825,0.002101059,0.001256606,0.000360569,0.02009948],"genre_scores_gemma":[0.9945915,0.001232248,0.001613841,0.001368512,0.00005130258,0.0001445415,0.0005346535,0.00002209954,0.000441285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8578175,"threshold_uncertainty_score":0.4949691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732063647863826,"score_gpt":0.2938223368248847,"score_spread":0.2765017003462465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}