{"id":"W4226094138","doi":"10.1080/15548627.2022.2039994","title":"Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases","year":2022,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of General Medical Sciences; Canceropôle Provence-Alpes-Côte d’Azur; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Autophagy; Biology; Single-nucleotide polymorphism; SNP; Etiology; Gene; Bioinformatics; Genetics; Microbiome; Immunology; Medicine; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004109053,0.0005752704,0.001070328,0.000508207,0.001072877,0.00003982001,0.0006637853,0.0001418465,0.01007596],"category_scores_gemma":[0.0002511699,0.000528771,0.0004572986,0.0006904131,0.0001792255,0.0001524113,0.0004052636,0.0003731818,0.0001491155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004032249,"about_ca_system_score_gemma":0.000313474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004134339,"about_ca_topic_score_gemma":0.000006017956,"domain_scores_codex":[0.9957426,0.0001901071,0.0009022775,0.001187596,0.001143236,0.0008342158],"domain_scores_gemma":[0.9969422,0.000405778,0.000266879,0.00133891,0.0001679174,0.0008783052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00586041,0.003832955,0.002595531,0.0001732204,0.001442945,0.001986874,0.005892326,0.0005714838,0.790944,0.0152487,0.08853692,0.08291462],"study_design_scores_gemma":[0.02789483,0.01339922,0.3188538,0.0003585889,0.002195944,0.0003029584,0.0009053719,0.002620455,0.2980218,0.05867234,0.2744795,0.002295193],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761979,0.009853279,0.003346903,0.002932804,0.001841835,0.002701737,0.00141116,0.0008123016,0.0009020947],"genre_scores_gemma":[0.9759862,0.00005084557,0.001705278,0.00988503,0.001721788,0.001689429,0.001510417,0.0001772053,0.007273737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4929222,"threshold_uncertainty_score":0.9997164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403793065368919,"score_gpt":0.3196115467439992,"score_spread":0.29557361609031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}