{"id":"W4226101007","doi":"10.1016/j.celrep.2021.110208","title":"Subcellular and regional localization of mRNA translation in midbrain dopamine neurons","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Institutes of Health; JPB Foundation; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; National Institute of Neurological Disorders and Stroke; LabEx BRAIN; Pakistan Academy of Sciences; Centre National de la Recherche Scientifique; Aligning Science Across Parkinson’s; Agence Nationale de la Recherche; Eastern Health; Michael J. Fox Foundation for Parkinson's Research","keywords":"Translation (biology); Substantia nigra; Messenger RNA; Cell biology; Midbrain; Biology; Dopamine; Dopaminergic; Subcellular localization; Ribosome; RNA; Neuroscience; Biochemistry; Central nervous system; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002024866,0.00006923224,0.00008507205,0.00005460447,0.00004558858,0.000003139386,0.00003040209,0.0000444997,0.00003716082],"category_scores_gemma":[0.000006339537,0.00008070409,0.00003989065,0.00009603005,0.00003452693,0.000002717624,0.00001710507,0.00005772994,9.067836e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006973918,"about_ca_system_score_gemma":0.00003477297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003711139,"about_ca_topic_score_gemma":0.00003674062,"domain_scores_codex":[0.9992684,0.00004215066,0.00025364,0.0002215782,0.0001277504,0.00008651914],"domain_scores_gemma":[0.9996909,0.000005023032,0.0001057359,0.0001506153,0.00001922882,0.00002843826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004702346,0.00007119786,0.03846353,0.00002911809,0.000003432913,0.00009110386,0.0001209167,0.001580934,0.9589779,0.00001175834,0.00003560171,0.0005674389],"study_design_scores_gemma":[0.001434405,0.0006179484,0.02382925,0.00001731234,0.00005210208,0.0004553671,0.0003676114,0.006126241,0.6314602,0.0003909902,0.334774,0.0004744473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870796,0.001665044,0.01048037,0.0000531533,0.00007062365,0.0001396523,0.000003542698,0.000004290232,0.0005037524],"genre_scores_gemma":[0.9969574,0.0001240368,0.0000715682,0.00003871227,0.00002307916,0.00001054631,0.002520813,0.00001123843,0.0002425603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3347384,"threshold_uncertainty_score":0.3291017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094456077204769,"score_gpt":0.2044334126480581,"score_spread":0.1934888518760104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}