{"id":"W4226128154","doi":"10.3389/fcimb.2021.770478","title":"Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Filamentation; Candida albicans; Biology; Transcription factor; Cell biology; Corpus albicans; Virulence; Gene; Phenotype; Transcriptional regulation; Genetics; Fungal protein; Gene regulatory network; Mutant; Genetic screen; Regulation of gene expression; Hypha; Gene expression; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006138836,0.00009760038,0.0002889626,0.000165344,0.0000905761,0.000003230342,0.00005986963,0.00007809333,0.0001448117],"category_scores_gemma":[0.00003083702,0.00007779993,0.0000893698,0.0002166919,0.0001851026,0.00003184824,0.00001416325,0.0003272535,6.614144e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009581939,"about_ca_system_score_gemma":0.00007831826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267433,"about_ca_topic_score_gemma":0.0001410847,"domain_scores_codex":[0.9988916,0.0003601889,0.0002763936,0.0002175202,0.00006746006,0.0001868505],"domain_scores_gemma":[0.9997379,0.00004466127,0.00005632393,0.0001062996,0.00002843233,0.00002634996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004128148,0.0001970586,0.6831146,0.00003389583,0.00002356671,0.00002225737,0.0003661565,0.00001304674,0.3146427,0.0002747664,0.0005701364,0.0003289646],"study_design_scores_gemma":[0.008528579,0.001455135,0.9510099,0.0000269913,0.0001358356,0.00041847,0.002077099,0.0003953057,0.005704889,0.0009986296,0.02897522,0.0002739945],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903333,0.002441309,0.005650636,0.0003177883,0.000416515,0.0003426128,0.0001245368,0.00000675622,0.000366609],"genre_scores_gemma":[0.9990486,0.0001579714,0.0000927279,0.0004165137,0.00003586333,0.00003498072,0.0001036044,0.000006156059,0.0001035783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3089378,"threshold_uncertainty_score":0.3172589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007176190776924224,"score_gpt":0.2080955387517598,"score_spread":0.2009193479748356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}