{"id":"W4226128154","doi":"10.3389/fcimb.2021.770478","title":"Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Filamentation; Candida albicans; Biology; Transcription factor; Cell biology; Corpus albicans; Virulence; Gene; Phenotype; Transcriptional regulation; Genetics; Fungal protein; Gene regulatory network; Mutant; Genetic screen; Regulation of gene expression; Hypha; Gene expression; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606366,0.0002354106,0.0002639936,0.0003557603,0.0002093313,0.0003543646,0.000174517,0.000167469,0.000668643],"category_scores_gemma":[0.0002068508,0.0001161614,0.000236492,0.0001802686,0.0003191093,0.0001103818,0.0004920728,0.0003918959,0.0002088345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004001828,"about_ca_system_score_gemma":0.0002750113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293919,"about_ca_topic_score_gemma":0.001740435,"domain_scores_codex":[0.9997181,0.00003558361,0.0000149912,0.00008711383,0.00008195599,0.00006211938],"domain_scores_gemma":[0.9998467,0.00003660816,0.00003185058,0.00001470086,0.00003649612,0.00003371794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006457363,0.00001101103,0.0004786383,0.00001548925,0.000002505425,0.00002700956,0.00001785008,0.00005328364,0.9979772,0.0001316094,0.00003892823,0.00118188],"study_design_scores_gemma":[0.00002125788,0.0001677994,0.09824874,0.00001722977,0.00002506661,0.000224524,0.000220991,0.00636438,0.8915112,0.0003619057,0.002814539,0.00002228631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991516,0.001414062,0.003499585,0.0001755637,0.0000343493,0.00002202485,0.001114535,0.0001245726,0.002099275],"genre_scores_gemma":[0.9946978,0.0006012454,0.001858022,0.000122281,0.00001421689,0.00003174418,0.001025221,0.000029569,0.001619912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293919,"threshold_uncertainty_score":0.002903581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007176190776924224,"score_gpt":0.2080955387517598,"score_spread":0.2009193479748356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}