{"id":"W4226136137","doi":"10.1101/2022.04.05.487163","title":"Unexpected contributions of striatal projection neurons coexpressing dopamine D1 and D2 receptors in balancing motor control","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Douglas College","funders":"Fonds De La Recherche Scientifique - FNRS","keywords":"Neuroscience; Striatum; Dopamine receptor D2; Direct pathway of movement; Dopaminergic; Optogenetics; Medium spiny neuron; Efferent; Indirect pathway of movement; Dopamine; Raclopride; Population; Globus pallidus; Basal ganglia; Psychology; Biology; Medicine; Central nervous system; Afferent","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000932404,0.0001932087,0.0002072569,0.00009949578,0.0001358905,0.0003109744,0.0001757987,0.0002567921,0.001829029],"category_scores_gemma":[0.0001238124,0.00007720977,0.0001503691,0.00005699541,0.0001691981,0.0001906133,0.0002906043,0.0003396546,0.0002553619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000132708,"about_ca_system_score_gemma":0.0001292759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002250601,"about_ca_topic_score_gemma":0.0006845985,"domain_scores_codex":[0.9999506,0.000003902123,0.000005227661,0.00001474387,0.00001454316,0.00001086573],"domain_scores_gemma":[0.9999193,0.00001669973,0.00001210511,0.000007781909,0.0000151303,0.00002891253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001117366,0.000009149413,0.0006427292,0.00003135116,0.000005621683,0.0001796889,0.000008450646,0.00003003355,0.9966594,0.0001174559,0.00006132409,0.002143114],"study_design_scores_gemma":[0.0000655921,0.000674775,0.08899078,0.00001891699,0.000104053,0.003658395,0.0002774106,0.003976987,0.8953144,0.0006468013,0.006240265,0.00003156419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938471,0.0009579473,0.002819208,0.0001412715,0.00007403266,0.00001017603,0.0001224825,0.00003557974,0.001992297],"genre_scores_gemma":[0.9947973,0.0005669505,0.001523542,0.0001040941,0.00003164078,0.00001128562,0.0001361459,0.00002224723,0.002806855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829029,"threshold_uncertainty_score":0.006118715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179037979551143,"score_gpt":0.2417074015295659,"score_spread":0.2299170217340545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}