{"id":"W4226141352","doi":"10.1002/trc2.12283","title":"Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University; University Health Network; Dalhousie University","funders":"","keywords":"Innate immune system; Microglia; Neuroscience; Biology; Immunology; Immunity; Inflammation; Cell biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003574851,0.0003363662,0.000518971,0.0004984319,0.001578919,0.0001243982,0.001602948,0.000110562,0.009440919],"category_scores_gemma":[0.001049747,0.0003559228,0.001120461,0.0015207,0.001180476,0.0006630634,0.0005207203,0.001392494,0.00009727836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001494843,"about_ca_system_score_gemma":0.0004198381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006881861,"about_ca_topic_score_gemma":0.00008873305,"domain_scores_codex":[0.9891466,0.005081884,0.001885597,0.00101152,0.002026713,0.0008476194],"domain_scores_gemma":[0.9959704,0.001891379,0.0003500809,0.0009334732,0.000331959,0.000522753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.007194667,0.08148158,0.02872936,0.0002121691,0.02597632,0.0001895947,0.003501494,0.003686774,0.3221223,0.192165,0.008270477,0.3264703],"study_design_scores_gemma":[0.02170188,0.00919185,0.4479511,0.0003225203,0.0102804,0.00004688182,0.002757562,0.02891687,0.1017743,0.2224014,0.1510445,0.003610761],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9128317,0.07717571,0.0008425132,0.003430462,0.0005608298,0.001844262,0.001956824,0.000200067,0.001157632],"genre_scores_gemma":[0.9974176,0.000479273,0.0002906531,0.0003134066,0.00004696437,0.0004297399,0.0008330307,0.00006964429,0.000119663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4192217,"threshold_uncertainty_score":0.9998893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2258525202017929,"score_gpt":0.4530763106408799,"score_spread":0.227223790439087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}