{"id":"W4226141352","doi":"10.1002/trc2.12283","title":"Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University; University Health Network; Dalhousie University","funders":"","keywords":"Innate immune system; Microglia; Neuroscience; Biology; Immunology; Immunity; Inflammation; Cell biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198903,0.0003993115,0.0002855618,0.0001986477,0.0001793652,0.0004078922,0.0001983472,0.0002604336,0.001144932],"category_scores_gemma":[0.0000593656,0.00008499483,0.0002595714,0.0001652442,0.0003708132,0.0003068706,0.000202855,0.0003134096,0.0002428818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420057,"about_ca_system_score_gemma":0.0003373588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002477055,"about_ca_topic_score_gemma":0.0003785533,"domain_scores_codex":[0.9999217,0.00002400505,0.000008371185,0.00001653114,0.00001472026,0.00001480233],"domain_scores_gemma":[0.9999586,0.000005449363,0.00001626031,0.000005408318,0.000008254418,0.000006080132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009222342,0.0002927434,0.01076608,0.001920736,0.0001237869,0.003544718,0.0003052602,0.0007546207,0.9209419,0.00650355,0.0009207696,0.05300348],"study_design_scores_gemma":[0.0004482759,0.005451607,0.08712853,0.001016155,0.0009116415,0.03167178,0.0007723738,0.005900821,0.7091363,0.02108395,0.1363545,0.0001240654],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8660993,0.1093759,0.009919937,0.0007332379,0.0002421045,0.0001770658,0.0004246131,0.0001722528,0.01285564],"genre_scores_gemma":[0.9679531,0.02541652,0.003877837,0.0002459504,0.0001160958,0.00004931224,0.0001807188,0.000007512857,0.002152933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144932,"threshold_uncertainty_score":0.003830254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2258525202017929,"score_gpt":0.4530763106408799,"score_spread":0.227223790439087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}