{"id":"W4226145696","doi":"10.1038/s41525-022-00299-9","title":"Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease","year":2022,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; St. Michael's Hospital; Institut universitaire de cardiologie et de pneumologie de Québec; Memorial University of Newfoundland; Foothills Medical Centre; London Health Sciences Centre; St. Paul's Hospital; Izaak Walton Killam Health Centre; Alberta Children's Hospital; University of Saskatchewan; Hospital for Sick Children; Université de Montréal; Queen Elizabeth II Health Sciences Centre; Children's Hospital of Eastern Ontario; Université Laval; BC Children's Hospital; Centre Hospitalier de l’Université de Montréal; Kingston Health Sciences Centre; Public Health Ontario; University of Toronto","funders":"Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Government of Canada; Canadian Institutes of Health Research; Genome Canada; Government of Ontario; Medical Research Council; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Medicine; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; COPD; Population; Spirometry; Internal medicine; Biobank; Lung; Pharmacology; Bioinformatics; Oncology; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008837624,0.0001553043,0.0003710283,0.00008039013,0.0003260017,0.000003325711,0.0002466524,0.0000127961,0.0009354502],"category_scores_gemma":[0.000519626,0.0000743987,0.00009967307,0.000175279,0.0003301672,0.00002011498,0.00008325818,0.00008670671,0.000001315696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002715653,"about_ca_system_score_gemma":0.000586316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005134544,"about_ca_topic_score_gemma":0.00001064634,"domain_scores_codex":[0.998123,0.00009744245,0.000595983,0.0002427095,0.0006537371,0.0002870842],"domain_scores_gemma":[0.9973757,0.001656573,0.0002378208,0.0004797327,0.0001234856,0.000126722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007209018,0.001012249,0.1287512,0.00198573,0.001594975,0.00005839498,0.06984448,0.001717603,0.4911155,0.0001733439,0.01207838,0.2844591],"study_design_scores_gemma":[0.007066701,0.005619119,0.6508293,0.0007809373,0.001351756,0.00004550354,0.01744323,0.01034721,0.01088298,0.0004272142,0.294852,0.0003539988],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8842333,0.1032703,0.002632623,0.006971696,0.0002709942,0.002536693,0.00003167304,0.0000148779,0.00003783756],"genre_scores_gemma":[0.9926019,0.001677446,0.004022605,0.0001357289,0.0002341353,0.0007069396,0.00002505598,0.00002405772,0.0005721467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5220781,"threshold_uncertainty_score":0.9999778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04206895924006237,"score_gpt":0.3447969348603585,"score_spread":0.3027279756202961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}