{"id":"W4226145696","doi":"10.1038/s41525-022-00299-9","title":"Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease","year":2022,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; St. Michael's Hospital; Institut universitaire de cardiologie et de pneumologie de Québec; Memorial University of Newfoundland; Foothills Medical Centre; London Health Sciences Centre; St. Paul's Hospital; Izaak Walton Killam Health Centre; Alberta Children's Hospital; University of Saskatchewan; Hospital for Sick Children; Université de Montréal; Queen Elizabeth II Health Sciences Centre; Children's Hospital of Eastern Ontario; Université Laval; BC Children's Hospital; Centre Hospitalier de l’Université de Montréal; Kingston Health Sciences Centre; Public Health Ontario; University of Toronto","funders":"Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Government of Canada; Canadian Institutes of Health Research; Genome Canada; Government of Ontario; Medical Research Council; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Medicine; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; COPD; Population; Spirometry; Internal medicine; Biobank; Lung; Pharmacology; Bioinformatics; Oncology; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007449357,0.0005428378,0.001484122,0.0009378546,0.0003871007,0.001679412,0.001162124,0.001310161,0.01417217],"category_scores_gemma":[0.01684541,0.0003088644,0.004167148,0.001613243,0.0008586146,0.0006383409,0.0006270153,0.002274495,0.001082103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007831965,"about_ca_system_score_gemma":0.001410371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005951067,"about_ca_topic_score_gemma":0.008197895,"domain_scores_codex":[0.9965221,0.001574582,0.0003832447,0.0007293655,0.00065079,0.0001400062],"domain_scores_gemma":[0.9747244,0.01794955,0.003269897,0.00109145,0.002209002,0.0007557517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02264282,0.0003429232,0.3722778,0.0375942,0.1697368,0.002089167,0.0004005448,0.003971478,0.01503344,0.01174765,0.04397025,0.3201928],"study_design_scores_gemma":[0.003348161,0.003499812,0.61149,0.02019754,0.1684142,0.002947332,0.0007377921,0.003862992,0.003651006,0.0223044,0.1593999,0.0001467206],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1295307,0.8008412,0.005093059,0.0426034,0.002020101,0.0001312234,0.006799191,0.0001578758,0.01282324],"genre_scores_gemma":[0.8367398,0.1398548,0.003552618,0.01157235,0.002628723,0.00007119354,0.003569875,0.00008872754,0.001921977],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01417217,"threshold_uncertainty_score":0.04741061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04206895924006237,"score_gpt":0.3447969348603585,"score_spread":0.3027279756202961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}