{"id":"W4226152882","doi":"10.7554/elife.71825","title":"Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"GNAQ; Crosstalk; Melanoma; Cancer research; Oncogene; Biology; Medicine; Genetics; Cancer; Cell cycle; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503132,0.0003183584,0.0001839574,0.0002301235,0.0002138009,0.0003605404,0.0001386224,0.0003776604,0.002024849],"category_scores_gemma":[0.000125492,0.0001456506,0.0002396211,0.00008264077,0.0002430729,0.0002004316,0.0004205588,0.0005396501,0.0005947659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002803553,"about_ca_system_score_gemma":0.0001652607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000278098,"about_ca_topic_score_gemma":0.0005190896,"domain_scores_codex":[0.9997277,0.00005475892,0.00001349623,0.00006315487,0.00007470773,0.00006625072],"domain_scores_gemma":[0.9999238,0.000009155723,0.00002011241,0.00001417858,0.00000993327,0.00002279382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005350984,0.00001465318,0.000611977,0.00002017918,0.000004487936,0.000240057,0.00001246441,0.00003101062,0.9976356,0.00010835,0.00003084853,0.001236844],"study_design_scores_gemma":[0.00002151908,0.0005262475,0.01999749,0.0000131506,0.00003305227,0.005259494,0.0001765161,0.0008876845,0.9676474,0.0003921188,0.005034894,0.00001026345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919287,0.001364912,0.002279607,0.0001605995,0.00003073824,0.00003381606,0.00007088371,0.0001017078,0.004029013],"genre_scores_gemma":[0.9972339,0.000295243,0.0008314661,0.00006240506,0.000003462528,0.000009274498,0.00003679318,0.000008560543,0.001518843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002024849,"threshold_uncertainty_score":0.006773829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867768235535144,"score_gpt":0.2607521541158,"score_spread":0.2420744717604486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}