{"id":"W4226158664","doi":"10.1038/s41522-022-00270-7","title":"Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche","year":2022,"lang":"en","type":"article","venue":"npj Biofilms and Microbiomes","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; International Microbiome Centre, University of Calgary; Alberta Innovates - Health Solutions; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; National Institute of Allergy and Infectious Diseases; Government of Alberta; Alberta Innovates; University of Calgary","keywords":"Extracellular matrix; Coagulation; Niche; Protease; Microbiology; Biology; Medicine; Immunology; Internal medicine; Cell biology; Enzyme; Ecology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397522,0.0003366418,0.0002598047,0.0003597618,0.0002933818,0.0006817845,0.0001478228,0.0003256099,0.0006481953],"category_scores_gemma":[0.0003545553,0.0001330825,0.0002607991,0.0003663497,0.0001878877,0.0002570937,0.0004057818,0.0003383479,0.0002812873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847836,"about_ca_system_score_gemma":0.0004242756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001577261,"about_ca_topic_score_gemma":0.001417033,"domain_scores_codex":[0.9997566,0.00003438283,0.00001650398,0.00004933381,0.00008535286,0.00005784193],"domain_scores_gemma":[0.9998657,0.00001586658,0.00006567391,0.000009821645,0.00001825171,0.00002476469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001033134,0.00002501978,0.007189596,0.0001446771,0.00001905598,0.00053335,0.0001102024,0.0001201351,0.9832902,0.0001466415,0.0001869447,0.008130802],"study_design_scores_gemma":[0.00002418462,0.0003484595,0.2670503,0.0001517213,0.0001232357,0.008133079,0.001270227,0.004175949,0.6915469,0.0007991425,0.02633907,0.00003781133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864412,0.007767311,0.002317631,0.0002902448,0.0000233542,0.00003578766,0.0008725225,0.0000718094,0.002180007],"genre_scores_gemma":[0.9913325,0.002746685,0.003594635,0.00008849829,0.00001066131,0.00002399665,0.0009404063,0.00001771229,0.001244993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001577261,"threshold_uncertainty_score":0.003136158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625498155283786,"score_gpt":0.2701747260811096,"score_spread":0.2539197445282717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}