{"id":"W4226162025","doi":"10.1016/j.bpsgos.2021.11.012","title":"Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry Global Open Science","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Mental Health; National Institutes of Health","keywords":"Donepezil; Cognition; Dissociation (chemistry); Cognitive flexibility; Psychology; Pharmacology; Neuroscience; Medicine; Cognitive psychology; Chemistry; Internal medicine; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334698,0.0003767989,0.0004047262,0.0003629433,0.0001903387,0.0002473135,0.0002671021,0.0003044832,0.0006347552],"category_scores_gemma":[0.0002403922,0.0001743848,0.000369942,0.000109833,0.0004199411,0.0002433769,0.000205464,0.0007955916,0.000218199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004421453,"about_ca_system_score_gemma":0.0003656881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001975186,"about_ca_topic_score_gemma":0.004251051,"domain_scores_codex":[0.9998901,0.0000129797,0.00000952521,0.00002920443,0.00002057069,0.00003753644],"domain_scores_gemma":[0.9997951,0.0000414257,0.00004405313,0.00003783158,0.00003182878,0.00004975889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002061352,0.0005421402,0.0008597161,0.0001058182,0.00004377228,0.0001618655,0.00009123214,0.0001006764,0.9882542,0.00009378202,0.000167459,0.007517975],"study_design_scores_gemma":[0.0002792341,0.01341533,0.02751936,0.00004103412,0.0002009087,0.0005229182,0.0001709599,0.001191718,0.95303,0.0002818778,0.003311324,0.00003536637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995333,0.001827609,0.0006529056,0.0001834012,0.00003027634,0.00004951821,0.0002839504,0.00004814805,0.001591163],"genre_scores_gemma":[0.9948003,0.001549214,0.001109448,0.0001600238,0.00002063058,0.0001267066,0.0003647288,0.00002647936,0.001842418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975186,"threshold_uncertainty_score":0.00392735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08785244165296818,"score_gpt":0.4239717087653923,"score_spread":0.3361192671124241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}