{"id":"W4226164056","doi":"10.1038/s41420-021-00769-6","title":"Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer","year":2022,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Beijing Municipal Administration of Hospitals; National Natural Science Foundation of China","keywords":"Senescence; Cancer; Transcriptome; Gene signature; Cancer cell; Medicine; Oncology; Biology; Cancer research; Internal medicine; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004837126,0.0001623064,0.0003043103,0.0004069812,0.0001134228,0.0003769806,0.00008376767,0.0001528648,0.0003051708],"category_scores_gemma":[0.0005451498,0.00007671928,0.0001910863,0.0004869273,0.0001626911,0.000181969,0.0002532116,0.000224457,0.0001156753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773053,"about_ca_system_score_gemma":0.0002364713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004338172,"about_ca_topic_score_gemma":0.0006977192,"domain_scores_codex":[0.999853,0.00003331214,0.00001318244,0.00004340585,0.00003914524,0.00001788536],"domain_scores_gemma":[0.9998653,0.00002730498,0.00005489562,0.000013938,0.00002030303,0.00001829331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001786744,0.0001440025,0.3916574,0.0003677344,0.0002709819,0.0002513929,0.0004175236,0.006633507,0.5162714,0.00059026,0.001109665,0.0804993],"study_design_scores_gemma":[0.00002271126,0.0006821876,0.9119478,0.00003599684,0.0001745465,0.0005235045,0.0003159015,0.0180204,0.06331229,0.001236067,0.00369016,0.00003844475],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940572,0.002089129,0.002047382,0.00008814285,0.00000971018,0.00001520173,0.001221009,0.00003921377,0.0004329491],"genre_scores_gemma":[0.9971498,0.0006564294,0.000985987,0.00005100266,0.000008519882,0.00001810858,0.000905316,0.000005900542,0.00021896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004837126,"threshold_uncertainty_score":0.002558112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122684581598068,"score_gpt":0.2422624217901479,"score_spread":0.2310355759741672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}