{"id":"W4226164056","doi":"10.1038/s41420-021-00769-6","title":"Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer","year":2022,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Beijing Municipal Administration of Hospitals; National Natural Science Foundation of China","keywords":"Senescence; Cancer; Transcriptome; Gene signature; Cancer cell; Medicine; Oncology; Biology; Cancer research; Internal medicine; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004970362,0.0001080502,0.000139701,0.00004276041,0.00007399085,0.00001526121,0.0001094641,0.0000329123,0.00001648936],"category_scores_gemma":[0.000004683192,0.00009804273,0.00005684197,0.00007085022,0.00004858261,0.000003496412,0.00007627478,0.00007506712,2.322625e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001903759,"about_ca_system_score_gemma":0.00005659371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002632666,"about_ca_topic_score_gemma":0.00003875733,"domain_scores_codex":[0.9993077,0.00004718642,0.0001629433,0.0002137361,0.0001202775,0.0001481511],"domain_scores_gemma":[0.9997407,0.00001115252,0.00005934113,0.0001470862,0.00001165484,0.00003009079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006606668,0.0001762592,0.3312236,0.00002686932,0.00001601239,0.000004053308,0.0002218061,0.0003452341,0.6671025,0.00005901338,0.0000143252,0.0007443035],"study_design_scores_gemma":[0.00227565,0.001409787,0.2563359,0.00003571628,0.00006436941,0.00001256718,0.001081878,0.0001090198,0.7329757,0.000188706,0.004989817,0.0005208995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969931,0.002398221,0.00006642952,0.0000309021,0.0001101146,0.0001297149,0.00003700542,0.000003620809,0.000230926],"genre_scores_gemma":[0.999077,0.0001776351,0.00002604474,0.0002716882,0.00001277503,0.00003803738,0.00002259444,0.00001321133,0.0003610184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07488767,"threshold_uncertainty_score":0.3998066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122684581598068,"score_gpt":0.2422624217901479,"score_spread":0.2310355759741672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}