{"id":"W4226164885","doi":"10.1038/s41467-022-27996-4","title":"Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Genetics and Genomics of Geneva; Université de Genève; European Commission; National Science Foundation; Universiteit Stellenbosch; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Toxoplasma gondii; Biology; Protozoan parasite; Apicomplexa; Parasite hosting; Biosynthesis; Pathogen; Chronic infection; Protozoa; Coenzyme A; Gene; Secretion; Microbiology; Enzyme; Biochemistry; Plasmodium falciparum; Genetics; Immunology; Immune system; Malaria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008997134,0.0002902837,0.0003020868,0.0001614543,0.0002214637,0.0004966055,0.0001552474,0.00043665,0.001189967],"category_scores_gemma":[0.0002053493,0.0001613666,0.0001502567,0.0001414673,0.0003580693,0.0003409649,0.0003660293,0.0004537684,0.0004098002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004404024,"about_ca_system_score_gemma":0.0005095721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000981027,"about_ca_topic_score_gemma":0.002243761,"domain_scores_codex":[0.9998755,0.00001496613,0.00001301536,0.00002981598,0.00003016163,0.0000365158],"domain_scores_gemma":[0.9998463,0.00001320411,0.00005932084,0.000009741001,0.00002676979,0.0000445416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002617451,0.00001231941,0.001543164,0.0001054265,0.000007210016,0.0003401168,0.00003644175,0.00002621361,0.9950009,0.0001338657,0.0001558673,0.002376655],"study_design_scores_gemma":[0.00006730289,0.0008775956,0.1823629,0.0001522921,0.0001069798,0.006036777,0.0007486555,0.001531575,0.7826843,0.001969641,0.0234269,0.00003521199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833543,0.007968424,0.002919313,0.0008421713,0.0001257982,0.0000293973,0.000772486,0.0001518377,0.003836272],"genre_scores_gemma":[0.991402,0.003550016,0.002234616,0.0001525,0.00002702905,0.00002381575,0.0006281079,0.00003202151,0.001949798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189967,"threshold_uncertainty_score":0.003980875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04139037283518489,"score_gpt":0.3430800148239465,"score_spread":0.3016896419887616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}