{"id":"W4226177538","doi":"10.15252/embr.202153955","title":"Cardio‐respiratory and phenotypic rescue of dystrophin/utrophin‐deficient mice by combination therapy","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Tianjin Research Innovation Project for Postgraduate Students; National Key Research and Development Program of China; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Duchenne muscular dystrophy; Dystrophin; Exon skipping; Medicine; Utrophin; mdx mouse; Metformin; Morpholino; Muscular dystrophy; Genetic enhancement; Pharmacology; Internal medicine; Bioinformatics; Biology; Exon; Biochemistry; Gene; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000479015,0.0009871474,0.001090438,0.001214607,0.0003532424,0.0004549925,0.0006867124,0.001229996,0.001800042],"category_scores_gemma":[0.0002263903,0.0003928197,0.0006885211,0.0004177339,0.0006213182,0.0003866651,0.0005770716,0.001917871,0.00065301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000318526,"about_ca_system_score_gemma":0.0003280931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005036423,"about_ca_topic_score_gemma":0.001045418,"domain_scores_codex":[0.9993538,0.000115458,0.00007012861,0.000130447,0.0002043023,0.0001257289],"domain_scores_gemma":[0.9996198,0.00004706542,0.0001128893,0.00006129638,0.00002412559,0.0001348277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009004447,0.0001504757,0.0001907905,0.00005813079,0.00004122106,0.0002345423,0.00002509143,0.0002595431,0.9945847,0.0001853591,0.0002103396,0.003159202],"study_design_scores_gemma":[0.0007562247,0.003449639,0.00390924,0.00003262888,0.0002670216,0.001513317,0.00005358855,0.002316571,0.9782073,0.0001513569,0.009304433,0.00003863919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780256,0.005349446,0.008567642,0.0006755161,0.0002947669,0.0002399752,0.001381436,0.0005858591,0.004879694],"genre_scores_gemma":[0.9826869,0.00302957,0.006114547,0.0001666939,0.0001079898,0.0003665641,0.0009448167,0.0001366985,0.006446031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001800042,"threshold_uncertainty_score":0.006021678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007374520407916673,"score_gpt":0.2258799316919436,"score_spread":0.2185054112840269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}