{"id":"W4226177538","doi":"10.15252/embr.202153955","title":"Cardio‐respiratory and phenotypic rescue of dystrophin/utrophin‐deficient mice by combination therapy","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Tianjin Research Innovation Project for Postgraduate Students; National Key Research and Development Program of China; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Duchenne muscular dystrophy; Dystrophin; Exon skipping; Medicine; Utrophin; mdx mouse; Metformin; Morpholino; Muscular dystrophy; Genetic enhancement; Pharmacology; Internal medicine; Bioinformatics; Biology; Exon; Biochemistry; Gene; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329817,0.00009461144,0.0001353561,0.00002909427,0.0001390332,0.000004381739,0.00006637599,0.00005497296,0.00003403725],"category_scores_gemma":[0.00002534178,0.00009537357,0.00005884602,0.0000588689,0.00008071274,0.000002524417,0.0001030054,0.00008138107,3.049963e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009933598,"about_ca_system_score_gemma":0.00004882049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000488742,"about_ca_topic_score_gemma":0.000002290458,"domain_scores_codex":[0.9991308,0.0001065618,0.0002145357,0.0002935443,0.0001306412,0.0001238934],"domain_scores_gemma":[0.9995188,0.000005983254,0.0001361244,0.0002625491,0.00004185671,0.00003466575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489846,0.0001571243,0.003122882,0.00001186962,0.00004933689,0.00001302327,0.00007145027,0.0003962853,0.9889231,0.0001286219,0.005700541,0.001276798],"study_design_scores_gemma":[0.00338595,0.004251244,0.08912437,0.00001229117,0.00006554471,0.0002380066,0.0007107081,0.00008478222,0.6086527,0.002691667,0.2898944,0.0008883554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932624,0.005380183,0.00005282752,0.00005723194,0.0001900045,0.0001615704,0.00001410538,0.000008028969,0.0008736133],"genre_scores_gemma":[0.9992282,0.0001055688,0.00001749737,0.000287293,0.00003017884,0.00004089146,0.0001180844,0.00001205268,0.0001602482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3802704,"threshold_uncertainty_score":0.3889221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007374520407916673,"score_gpt":0.2258799316919436,"score_spread":0.2185054112840269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}