{"id":"W4226191600","doi":"10.1101/2022.04.06.487353","title":"Bps polysaccharide of <i>Bordetella pertussis</i> resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts <i>Escherichia coli</i> into a respiratory pathogen","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Ohio State University","keywords":"Microbiology; Bordetella pertussis; Biology; Pathogen; Antimicrobial peptides; Escherichia coli; Antimicrobial; Bacteria; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008209034,0.0003622478,0.0001352155,0.0001231571,0.00007900992,0.0002249208,0.0001392897,0.0001993667,0.0006785154],"category_scores_gemma":[0.00006909461,0.00009460522,0.0002224617,0.00008750684,0.0001495673,0.0001147204,0.0001555927,0.0004598033,0.0002470126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001585979,"about_ca_system_score_gemma":0.0001268865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003551983,"about_ca_topic_score_gemma":0.0003303706,"domain_scores_codex":[0.9999098,0.00001781089,0.000008323553,0.00001307496,0.00002868162,0.00002226249],"domain_scores_gemma":[0.9999356,0.000006351465,0.00002616794,0.000007424723,0.000006560535,0.0000177966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002756645,0.000008862289,0.00009213825,0.000009367676,0.000001384471,0.0000101397,0.000001782126,0.000009953152,0.9996623,0.00001549061,0.000004948094,0.0001560327],"study_design_scores_gemma":[0.00000593008,0.0003853279,0.005323131,0.000005328571,0.00001158752,0.0002043251,0.00001755723,0.0003399323,0.9928408,0.00002173917,0.0008423955,0.000001970769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974508,0.0003073328,0.00136471,0.00006347575,0.00001575859,0.000009810014,0.0001486422,0.00002465929,0.0006149122],"genre_scores_gemma":[0.9950145,0.0002630364,0.002199699,0.00005963948,0.00001074629,0.00001241633,0.0006509561,0.00001409885,0.001774842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006785154,"threshold_uncertainty_score":0.002269864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008829840684062125,"score_gpt":0.2117757229215565,"score_spread":0.2029458822374944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}