{"id":"W4226209341","doi":"10.2139/ssrn.4064345","title":"Synthesis and Characterization of an Orally Bioavailable Small Molecule Agonist of the Apelin Receptor","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Apelin; Agonist; Chemistry; Pharmacology; Receptor; Bioavailability; Stereochemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563212,0.0003293338,0.0003955365,0.000183144,0.0001682607,0.0002364445,0.0003729627,0.0003358907,0.002436161],"category_scores_gemma":[0.0001653731,0.0001701657,0.0002875255,0.0001388237,0.0001157201,0.0002442012,0.000185582,0.000571191,0.001024378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000166651,"about_ca_system_score_gemma":0.0002735714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002308593,"about_ca_topic_score_gemma":0.0004460134,"domain_scores_codex":[0.9999259,0.00001378304,0.000007355681,0.0000157736,0.00002045582,0.00001665421],"domain_scores_gemma":[0.9999492,0.00001057049,0.00001095971,0.000006525108,0.000007913096,0.00001481011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002225005,0.00007751457,0.00004193394,0.00009457299,0.00002182884,0.0002274091,0.00002293832,0.0002684255,0.9924711,0.0001626971,0.0001428736,0.006246072],"study_design_scores_gemma":[0.0002652877,0.003268649,0.0009663288,0.00001500977,0.00009264011,0.001080165,0.00004574216,0.001524106,0.9750524,0.0001382958,0.01752747,0.00002397334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458117,0.009025996,0.03476101,0.0005446864,0.0001809335,0.0007002351,0.001663465,0.0001792362,0.007132668],"genre_scores_gemma":[0.9547884,0.006256366,0.02005349,0.0002910045,0.0000770486,0.0002829837,0.002559772,0.00004965389,0.01564118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002436161,"threshold_uncertainty_score":0.008149743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116444070016303,"score_gpt":0.2507336624583914,"score_spread":0.2390892554567611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}