{"id":"W4226209341","doi":"10.2139/ssrn.4064345","title":"Synthesis and Characterization of an Orally Bioavailable Small Molecule Agonist of the Apelin Receptor","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Apelin; Agonist; Chemistry; Pharmacology; Receptor; Bioavailability; Stereochemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002023927,0.00009630507,0.0002285193,0.0001306918,0.0002043587,0.000010697,0.0002624229,0.0000681854,0.0005025413],"category_scores_gemma":[0.0003509133,0.00006732844,0.00008162812,0.000431237,0.0001776525,0.0000496019,0.0001327928,0.001483954,0.000004486764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003752457,"about_ca_system_score_gemma":0.002543017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006395223,"about_ca_topic_score_gemma":0.00003134778,"domain_scores_codex":[0.9978467,0.0002644242,0.0003641089,0.0001597757,0.0005908237,0.0007741174],"domain_scores_gemma":[0.9992075,0.0000670459,0.0002482712,0.0002124633,0.0001459581,0.0001187889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004516206,0.000259029,0.001187988,0.00003474139,0.0001377725,0.000003522722,0.00009183367,0.000001192867,0.9659096,0.001053781,0.0000290463,0.03083985],"study_design_scores_gemma":[0.008391353,0.01417771,0.05157423,0.0006432521,0.00105432,0.003328827,0.007351757,0.004256214,0.8794541,0.007636619,0.02124501,0.0008866468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996172,0.0005581084,0.0001802543,0.002646812,0.00006697545,0.0001649065,0.00001874879,0.000008641073,0.0001835861],"genre_scores_gemma":[0.995779,0.001681167,0.00008607682,0.0001037706,0.00006754229,0.000009392836,0.00001913515,0.00002342598,0.00223046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08645555,"threshold_uncertainty_score":0.6447123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116444070016303,"score_gpt":0.2507336624583914,"score_spread":0.2390892554567611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}