{"id":"W4226210299","doi":"10.1093/clinchem/hvac064","title":"Commentary on Perplexingly High Tacrolimus Concentrations in a Renal Transplant Patient with HIV","year":2022,"lang":"en","type":"letter","venue":"Clinical Chemistry","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tacrolimus; Medicine; Therapeutic drug monitoring; Pharmacology; Immunoassay; Calcineurin; Adverse effect; Therapeutic index; Immunosuppression; Immunosuppressive drug; Whole blood; Pharmacokinetics; Transplantation; Antibody; Internal medicine; Drug; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009574278,0.0003807832,0.0007456624,0.0000410487,0.00008816632,0.00001928183,0.0001468768,0.0004468946,0.00167476],"category_scores_gemma":[0.0000158007,0.0002912995,0.0002874086,0.0001212505,0.0001438809,0.00002497567,0.00001744259,0.00269847,0.00002027141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241573,"about_ca_system_score_gemma":0.0001751961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003801528,"about_ca_topic_score_gemma":0.000004522102,"domain_scores_codex":[0.9974853,0.00009760006,0.0008568024,0.0006252193,0.0005637124,0.000371316],"domain_scores_gemma":[0.998615,0.0005268363,0.0002237568,0.0004416502,0.00003412166,0.0001585929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004627215,0.002121463,0.1666104,0.001231124,0.001131962,0.05775927,0.0002826166,0.00009848197,0.00006244578,0.000006025501,0.7656211,0.0004478822],"study_design_scores_gemma":[0.02192985,0.003497422,0.008984828,0.004076411,0.001438817,0.001289118,0.00007804473,0.00005637146,0.002387671,0.00003273866,0.9552437,0.0009850477],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3065421,0.00009271561,0.00001221345,0.6863954,0.0002548343,0.0007718256,0.002097983,0.00007975436,0.003753205],"genre_scores_gemma":[0.2847555,0.0002309796,0.0002150175,0.6936593,0.001160909,0.0001830472,0.01802637,0.00006844704,0.001700436],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1896226,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02941892710977806,"score_gpt":0.3150130708910218,"score_spread":0.2855941437812438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}