{"id":"W4226210299","doi":"10.1093/clinchem/hvac064","title":"Commentary on Perplexingly High Tacrolimus Concentrations in a Renal Transplant Patient with HIV","year":2022,"lang":"en","type":"letter","venue":"Clinical Chemistry","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tacrolimus; Medicine; Therapeutic drug monitoring; Pharmacology; Immunoassay; Calcineurin; Adverse effect; Therapeutic index; Immunosuppression; Immunosuppressive drug; Whole blood; Pharmacokinetics; Transplantation; Antibody; Internal medicine; Drug; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001569839,0.001040226,0.001628337,0.0008223617,0.002094741,0.002011433,0.003502645,0.02957841,0.007597988],"category_scores_gemma":[0.01820349,0.0006077074,0.001452483,0.0005898701,0.001931589,0.003415013,0.001209584,0.02350602,0.004078659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003270392,"about_ca_system_score_gemma":0.002574633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004946204,"about_ca_topic_score_gemma":0.005268684,"domain_scores_codex":[0.997832,0.0007845,0.0003304124,0.0003279793,0.0004847983,0.0002402268],"domain_scores_gemma":[0.9916669,0.004803964,0.0004498362,0.0001597743,0.001989838,0.0009297864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.0000493481,0.00001994167,0.0005453958,0.0001997007,0.00002771966,0.0114423,0.0001536629,0.0001061573,0.0001219702,0.0007570577,0.9808841,0.005692727],"study_design_scores_gemma":[0.0002023317,0.0001834184,0.002529973,0.003577793,0.000122425,0.05406856,0.001527355,0.0009134434,0.0006796109,0.00632427,0.9296816,0.0001892613],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001919606,0.00512324,0.0004318319,0.8521835,0.1337483,0.00007104698,0.0002763045,0.0001454902,0.006100735],"genre_scores_gemma":[0.01407661,0.003681603,0.0004516067,0.8099204,0.1666699,0.00006906394,0.0001300626,0.00005717132,0.004943616],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02957841,"threshold_uncertainty_score":0.0254178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02941892710977806,"score_gpt":0.3150130708910218,"score_spread":0.2855941437812438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}