{"id":"W4226211328","doi":"10.1002/alz.056653","title":"Microglial activation and tau propagate jointly across Braak stages","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Université de Montréal; McGill University Health Centre; Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Microglia; Neocortex; Neuroscience; Population; Tau protein; Pathology; Psychology; Alzheimer's disease; Medicine; Disease; Internal medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535235,0.0003060543,0.0003100558,0.0009790055,0.0003005212,0.0006038172,0.0002682543,0.0002108913,0.001135339],"category_scores_gemma":[0.00132773,0.00028558,0.0002902035,0.0005499604,0.0004329128,0.0004874843,0.0004600683,0.0002941377,0.0002650018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002335708,"about_ca_system_score_gemma":0.0002036331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003372103,"about_ca_topic_score_gemma":0.005859905,"domain_scores_codex":[0.9997432,0.00005646883,0.00001670936,0.00007774045,0.00005394896,0.00005190314],"domain_scores_gemma":[0.9988459,0.0001841398,0.0005227771,0.0001481935,0.0002108111,0.00008822343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001056308,0.0001321356,0.7578381,0.0001163966,0.0004519346,0.001098358,0.0009288745,0.003276281,0.2050663,0.001020627,0.0004602274,0.02855443],"study_design_scores_gemma":[0.000008620677,0.0001307013,0.9896886,0.000006581467,0.00004163405,0.0008593688,0.0001558613,0.003944719,0.004012367,0.0008859943,0.0002514068,0.00001404014],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971979,0.0001177918,0.002145786,0.00001478858,0.000001962826,0.00001119467,0.0001003714,0.00003112019,0.0003790759],"genre_scores_gemma":[0.999091,0.0000295061,0.0006140533,0.000003844027,0.000002870402,0.000004690964,0.00007221274,0.000004395505,0.0001775078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003372103,"threshold_uncertainty_score":0.006704926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896639525236908,"score_gpt":0.3265147708826972,"score_spread":0.2975483756303281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}