{"id":"W4226247215","doi":"10.1016/bs.mcb.2022.01.003","title":"Assessment of eIF2α phosphorylation during immunogenic cell death","year":2022,"lang":"en","type":"article","venue":"Methods in cell biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Labex Immuno-Oncology; European Research Council; Cancéropôle Ile de France; Institut National Du Cancer; Institut Universitaire de France; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Fondation Philanthropia; Fondation Leducq; European Commission; Association pour la Recherche sur le Cancer; Bristol-Myers Squibb","keywords":"Biology; Endoplasmic reticulum; Cell biology; Calreticulin; Immunogenic cell death; Phosphorylation; eIF2; Kinase; EIF-2 kinase; Protein kinase A; Initiation factor; Unfolded protein response; Protein kinase R; Programmed cell death; Biochemistry; Ribosome; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; RNA; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005440249,0.0001249974,0.000194393,0.00007175967,0.00008093297,0.000003482697,0.0002137882,0.0000909489,0.0002287463],"category_scores_gemma":[0.00003375692,0.000126765,0.0001090056,0.0001077065,0.00004870706,0.000001476551,0.0003244339,0.0001497736,7.726255e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003467947,"about_ca_system_score_gemma":0.00008923877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005856472,"about_ca_topic_score_gemma":0.000002585348,"domain_scores_codex":[0.9983928,0.0006679014,0.0003051622,0.0003415108,0.00006740558,0.000225221],"domain_scores_gemma":[0.9993945,0.00005191979,0.0001533513,0.0003331782,0.00002546074,0.00004162962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005833744,0.0001456979,0.0696483,0.00003203869,0.00001121537,0.000003109179,0.00002108221,0.001373503,0.9275209,0.00009569595,0.00001359524,0.001076482],"study_design_scores_gemma":[0.0009843641,0.0002948837,0.03108333,0.000002339749,0.00001707582,0.000003809534,0.0001571292,0.0004945541,0.9634876,0.0002622836,0.003051284,0.0001613702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807789,0.002448897,0.008309103,0.000009662211,0.0002379611,0.0001598665,0.00003964333,0.000006060219,0.008009919],"genre_scores_gemma":[0.9299035,0.000305651,0.06919826,0.00003779306,0.00002763985,0.00007981995,0.0001328199,0.00001407288,0.0003004118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06088915,"threshold_uncertainty_score":0.5169326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494275223040973,"score_gpt":0.3521424844344798,"score_spread":0.33719973220407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}