{"id":"W4226281599","doi":"10.1172/jci145343","title":"Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia; Spinal Cord Injury BC","funders":"Weill Cornell Medical College; National Cancer Institute; BC Cancer Foundation; Terry Fox Research Institute; Genome British Columbia; Michael Smith Health Research BC; Leukemia and Lymphoma Society of Canada; Canadian Institutes of Health Research; Genome Canada; Uehara Memorial Foundation; Leukemia and Lymphoma Society","keywords":"Diffuse large B-cell lymphoma; EZH2; Lymphoma; Tumor microenvironment; Epigenetics; Immune system; Somatic cell; Antigen; Reprogramming","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008972587,0.0001711492,0.0001585213,0.0001556341,0.00008020387,0.0001823843,0.0001065213,0.0001968351,0.001211051],"category_scores_gemma":[0.00008971441,0.00008961326,0.0001309535,0.00009364038,0.0001618813,0.0001682361,0.0002027057,0.0003730804,0.000294585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129652,"about_ca_system_score_gemma":0.00006002451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008455312,"about_ca_topic_score_gemma":0.0002134229,"domain_scores_codex":[0.999912,0.00001599488,0.00000426956,0.00002073094,0.00001974662,0.00002720286],"domain_scores_gemma":[0.9999483,0.000007491833,0.00001396877,0.000008309422,0.000004059352,0.00001798583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008830493,0.000009624436,0.0004557494,0.0000134093,0.000003296225,0.00005213769,0.000004241961,0.00002424956,0.9981349,0.00006468048,0.0000206015,0.001128833],"study_design_scores_gemma":[0.00003544443,0.0006575221,0.03524097,0.000003823047,0.00003547348,0.002317801,0.0000441868,0.001193447,0.9558698,0.0001480296,0.004447291,0.000006216496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959339,0.001562408,0.001409345,0.00005472631,0.000009296602,0.00000620849,0.0001063458,0.00004574552,0.0008721848],"genre_scores_gemma":[0.9984444,0.0002315619,0.0003104483,0.00002189713,0.000003560624,0.000005675164,0.0001338846,0.000004851014,0.000843725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211051,"threshold_uncertainty_score":0.004051328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04889366279214567,"score_gpt":0.3049443418095965,"score_spread":0.2560506790174508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}