{"id":"W4226282582","doi":"10.2139/ssrn.4071020","title":"Dynamic Control of Metabolic Zonation and Liver Repair by Endothelial Cell Wnt2 and Wnt9b Revealed by Single Cell Spatial Transcriptomics Using Molecular Cartography","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Transcriptome; Cell; Cell biology; Biology; Computational biology; Medicine; Cartography; Geography; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005904239,0.0002370066,0.0003013488,0.0001044093,0.0002520829,0.00002810285,0.0001615371,0.0001204409,0.00000767415],"category_scores_gemma":[0.000009530659,0.0002582892,0.000214632,0.0001087837,0.0001075252,0.00001297353,0.0000348877,0.0006332272,1.169126e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008693666,"about_ca_system_score_gemma":0.0003458133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002898327,"about_ca_topic_score_gemma":0.0001422323,"domain_scores_codex":[0.9979461,0.0002465163,0.0003763073,0.0003591294,0.0002472633,0.0008247292],"domain_scores_gemma":[0.9994307,0.00001435704,0.0002296612,0.0001530402,0.00007516106,0.00009704915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003575508,0.0002300211,0.001601642,0.00002407223,0.0001518081,0.000002726101,0.00009791422,0.0001350322,0.9957723,0.0000962706,0.00003258945,0.001498095],"study_design_scores_gemma":[0.01450652,0.004629266,0.0002559796,0.00001972285,0.001068093,0.000692491,0.001098365,0.01631866,0.9439263,0.001716095,0.0145998,0.001168663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8869208,0.05192752,0.06051679,0.00003905376,0.0001313964,0.0002211544,0.0001949049,0.000009900627,0.0000385139],"genre_scores_gemma":[0.9924207,0.00676218,0.0003655943,0.000128963,0.00006161277,0.000007537787,0.00007463946,0.00004609433,0.0001326524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1055,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003217810213070992,"score_gpt":0.1816709560405883,"score_spread":0.1784531458275173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}