{"id":"W4226293772","doi":"10.1186/s40168-022-01247-6","title":"Gut microbiome signatures linked to HIV-1 reservoir size and viremia control","year":2022,"lang":"en","type":"article","venue":"Microbiome","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona; Medical Research Council; Instituto de Salud Carlos III; National Institute for Health and Care Research; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; National Institutes of Health; Ministerio de Ciencia, Innovación y Universidades","keywords":"Biology; Microbiome; Clostridiales; Metabolome; Viremia; Gut flora; Immunology; Immune system; Metagenomics; Microbiology; Clostridium; Bioinformatics; Genetics; Metabolomics; Bacteria; Human immunodeficiency virus (HIV); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008649037,0.0003321948,0.0005182005,0.0002881195,0.0002641532,0.0007611496,0.0002343335,0.0003765799,0.002230807],"category_scores_gemma":[0.001072964,0.0001738817,0.0002350161,0.0003269752,0.0001811053,0.0002978377,0.0004855231,0.0004964512,0.0001953684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002459576,"about_ca_system_score_gemma":0.0003575798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004505071,"about_ca_topic_score_gemma":0.0007993456,"domain_scores_codex":[0.9997041,0.00008112473,0.00001516524,0.00007670377,0.00007055589,0.00005240264],"domain_scores_gemma":[0.9994459,0.0001378237,0.0001792606,0.00004121306,0.0000887284,0.0001069887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01784796,0.001291093,0.6467361,0.0006969824,0.000563055,0.0001296936,0.0003218085,0.001223959,0.2427156,0.0001440012,0.001141053,0.08718877],"study_design_scores_gemma":[0.0002278938,0.005201575,0.9706458,0.0001173076,0.0004462049,0.0004640078,0.000239279,0.002330207,0.01785833,0.0002515901,0.002188426,0.0000293522],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961718,0.001509068,0.0006004659,0.0000602,0.00001233279,0.00007269938,0.0009665365,0.0000181832,0.0005887208],"genre_scores_gemma":[0.9964839,0.0003820732,0.001401214,0.00007024457,0.00001698282,0.0001181833,0.001183492,0.000009015845,0.0003348355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002230807,"threshold_uncertainty_score":0.00746274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004822219270955365,"score_gpt":0.2333599994781005,"score_spread":0.2285377802071451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}